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别再乱涂护肤品了!长痘和湿疹的根源,其实在你的肠道里【TED

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时间英文中文
0:012,000 years ago, Hippocrates said all diseases start in the gut.2千年前,希波克拉底说所有的疾病都从肠道开始.
0:07Well, he was 30% right.嗯,他30%的权利。
0:09Today, I'm going to take you on a journey of how to solve skin problems今天,我带你去一个 如何解决皮肤问题的旅程
0:15starting in the gut, not forgetting your brain,从肠胃开始, 不要忘记你的大脑,
0:18and discovering your microbiome.发现你的微生物
0:20Now, how did an electrical engineer like me像我这样的电气工程师是怎么做到的
0:23end up solving skin problems from the inside out?最后从内部解决皮肤问题?
0:26Well, it started with my son, who had a severe allergy to preservative开始于我儿子 他对防腐剂过敏
0:32that was triggered by contact dermatitis.是由接触性皮炎引发的
0:35The contact dermatitis led to atopic dermatitis,接触性皮炎导致一个专题性皮炎,
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序号英文中文
12,000 years ago, Hippocrates said all diseases start in the gut.2千年前,希波克拉底说所有的疾病都从肠道开始.
2Well, he was 30% right.嗯,他30%的权利。
3Today, I'm going to take you on a journey of how to solve skin problems今天,我带你去一个 如何解决皮肤问题的旅程
4starting in the gut, not forgetting your brain,从肠胃开始, 不要忘记你的大脑,
5and discovering your microbiome.发现你的微生物
6Now, how did an electrical engineer like me像我这样的电气工程师是怎么做到的
7end up solving skin problems from the inside out?最后从内部解决皮肤问题?
8Well, it started with my son, who had a severe allergy to preservative开始于我儿子 他对防腐剂过敏
9that was triggered by contact dermatitis.是由接触性皮炎引发的
10The contact dermatitis led to atopic dermatitis,接触性皮炎导致一个专题性皮炎,
11which we also call eczema, and then ADHD.我们还称它为阴道炎 然后是ADHD
12Now, he also has moderate teenage acne.现在,他也有 中度的青少年疮。
13Being a mom, I wanted the best for my child,作为一个母亲,我最想为我的孩子着想
14so I searched for alternative preservatives, corticosteroids,所以我找了其他防腐剂 皮质类固醇
15isotretinoins, benzoyl peroxide.过氧化苯甲酰胺。
16Well, I didn't find much.嗯,我没有找到很多。
17So, necessity being the mother of invention,所以,必须成为发明之母,
18I decided to change fields and develop new technologies我决定改变领域,开发新技术
19that wouldn't have side effects.不会有副作用的
20Now, it's a mission to fundamentally transform two industries,现在,这是一个任务 从根本上改造两个行业,
21skin care and dermatology,皮肤护理和皮肤科,
22because technologies there have not changed significantly in 50 years.因为技术在50年里没有多大变化。
23We're going to be learning about the skin-gut-brain biome,我们将要了解 皮毛脑生物群落,
24so I want all of you to imagine所以我希望你们都能想象
25that your gut is in two-way communication with your brain,你的直觉与你的大脑有双向交流
26both are in two-way communication with your skin,都和你的皮肤有双向交流
27and all three are in two-way communication with your microbiome.三个都与你的微生物体进行双向交流
28For those of you to whom the microbiome is new,对于你们中那些 微生素是新的,
29know that we have 30 trillion human cells in our body,我们体内有30万亿个细胞
30but we carry around with us 100 trillion non-human cells.但我们带着100兆个非人类细胞
31These are bacteria, yeasts, fungi, etc.这些是细菌,酵母,真菌等.
32These are what make up our microbiomes.这些是组成我们的微生物的
33So, we're not as human as we think,所以,我们不是像我们想象中那样的人
34and yet our lives literally depend on these microorganisms.然而我们的生命却依赖于这些微生物。
35The gut, for example, it starts in your mouth.比如说,肠道是从你嘴里开始的
36The gut microbiome, it runs 10 meters through your digestive tract肠道微生物 穿过你的消化道10米
37and ends in your anus.结束在肛门。
38It helps us digest food.它帮助我们消化食物。
39It also synthesizes key vitamins.它还合成关键维生素.
40It also affects our immunity, our mental health, our hormonal balance.这也影响了我们的免疫力,我们的精神健康,我们的荷尔蒙平衡.
41Amazing, isn't it?太神奇了,不是吗?
42And without the gut microbiome, we would not last very long,没有肠道微生物, 我们不会持续太久,
43because we wouldn't be able to pull nutrients out of the food we eat.因为我们无法从食物中提取养分
44Our skin, too, is important,我们的皮肤也很重要
45and although its microbiome is not as rich as the gut,虽然它的微生物体并不像肠道那么丰富
46it protects us from infections.它保护我们免受感染。
47So, I want all of you to look around and say,所以,我希望你们大家看看周围,然后说,
48I am a complex skin, gut, brain biome system我是一个复杂的皮肤 肠道 大脑生物系统
49where everything is interconnected.在那里,一切都是相互关联的。
50Now, back to the preservative in my son.现在,回到我儿子的防腐剂。
51This preservative is used in over 50% of personal care products50%以上的个人护理产品使用这种防腐剂
52made in the world today,在今天的世界,
53and is considered safe at concentrations below 1%.且浓度低于1%被视为安全。
54However, at concentrations of more than 1%,然而,浓度超过1%,
55it can cause the common allergy called contact dermatitis,它可以引起常见的过敏,称为接触性皮炎,
56and in people that are susceptible, it can lead to eczema.而在易感染的人群中,它可以导致宫颈炎.
57This was the case with my son.我儿子就是这样
58And because the skin care industry is not regulated,因为皮肤护理行业没有受到监管
59manufacturers are not required to measure the concentration制造商不需要测量浓度
60of this preservative in their final formulation, let alone report it.更不要说报告了
61So, I will never know what happened.所以,我永远不会知道发生了什么。
62What I do know is that instead of becoming a happy soccer mom,我只知道 与其成为快乐的足球妈妈
63I became an unhappy eczema mom.我变成了一个不愉快的乳房妈妈。
64What that means is I was trying to minimize corticosteroids,这意味着我试图尽量减少皮质类固醇,
65and I was trying to slow down what's called the atopic march.我试图减慢所谓的主题游行。
66This is a progression of allergic diseases that starts with dry skin,这是从皮肤干燥开始的过敏性疾病的发展,
67but then evolves into eczema and food allergies,然后演变成宫颈和食物过敏
68and in some people, asthma,在一些人,哮喘,
69and a never-ending runny nose called rhinitis.和一个永无止境的鼻孔 叫做犀牛炎
70So, I became an expert in using coconut oil instead of diaper cream,所以我成了使用椰子油而不是尿布霜的专家
71in making my own vitamin B12 lotion by grinding vitamin B12 tablets,通过磨制维他命B12片来制作我的维生素B12乳液,
72and nightly rituals of colloidal oatmeal baths.和夜祭 共枕燕麦浴。
73And in this way, along with making all of his food,这样一来, 和他的所有食物,
74becoming an expert in organic cotton clothing, detergents, keeping diaries,成为有机棉衣、洗涤剂、日记方面的专家,
75by the time he was six, we had minimized his flare-ups,当他六岁时,我们把他的爆发降到最低
76and the eczema was limited to just his knees and his elbows,湿疹只局限于膝盖和肘部,
77and I thought the worst was over.我以为最糟糕的就结束了
78Well, no.嗯,没有。
79When he turned eight, he was diagnosed with ADHD.8岁时被诊断为ADHD.
80And it was only later that I found out that children who have eczema直到后来我才发现 患宫颈癌的孩子
81are at much higher risk of developing ADHD.发展ADHD的风险要高得多。
82In fact, their risk is 50% higher.事实上,他们的风险要高50%。
83Do we know why?知道为什么吗?
84No.没有
85What I did learn, though, was that the skin-gut microbiome is very real.不过,我所学到的是, 皮肤肿块的微生物是非常真实的。
86He was prescribed ADHD medication,他被开药了
87and for the first time I observed that if he ate protein for breakfast,我第一次看到 如果他吃蛋白质早餐
88the medication lasted longer, and in fact, he could focus.药物持续了更长的时间, 事实上,他可以集中精神。
89If he ate sugar, forget it.如果他吃了糖 就别管了
90It was a disaster.这是一个灾难。
91And so, this was my first experience, and this is how we got going.所以,这是我的首次经历, 这就是我们如何去。
92Now, I want to digress for a second and give you some numbers.现在,我想潜入一下, 给你一些数字。
93Did you know that 20% of newborns and children suffer from eczema?你知不知道20%的新生儿和儿童患上风疹?
94That's one in five.即为五分之一.
95And globally speaking, that's 500 million or half a billion little people.从全球来看, 也就是5亿或5亿个小人物。
96And it's not just the children who suffer, it's the families and the mothers.而受苦的不仅仅是孩子,而是家庭和母亲.
97And eczema is increasing in the world population, as is ADHD,和ADHD一样 Eczema在世界人口中不断增长
98so what are we doing wrong?我们做错了什么?
99The more I learned, the more I decided we had to change things.我学到的越多,就越决定我们必须改变一切。
100So I started with a preservative system and decided to create an alternative.于是我从防腐系统开始,决定建立一个替代品。
101The coconut oil was edible, you know, diaper cream, coconut oil.椰子油是可食用的,你知道的,尿布奶油,椰子油。
102So I thought maybe I can make a preservative system所以我想也许我可以做个防腐系统
103that is not only edible but safe for newborns.这不仅可以食用,而且对新生儿也是安全的。
104And I didn't know what to do, and one day I opened the fridge,我不知道该怎么办 有一天我打开冰箱
105and there was yogurt staring me in the face.有酸奶盯着我的脸。
106And that's when I had the epiphany, lactobacillus.那时我有了幻觉,乳房炎。
107Humans have been using lactobacillus to ferment and preserve food for thousands of years,人类利用乳房瘤发酵 保存食物数千年
108so why not use lactobacillus in skin care?为什么不在皮肤护理中使用乳房瘤?
109And this was where my career changed.这就是我事业的改变之处。
110I assembled a team and we developed the first biotech lactobacillus我组建了一个团队 我们开发了第一个生物技术乳房
111preservative system in the world that today has five years of shelf life世界上的防腐系统 今天有5年的保质期
112and can compete with any commercial preservative out there.并且可以和任何商业防腐剂竞争
113But more importantly, it does not disrupt your skin microbiome,但更重要的是,它不会扰乱你的皮肤微生,
114you know, those bacteria that keep us safe from infections.那些能使我们免于感染的细菌
115In fact, it mimics nature.事实上,它模仿自然。
116So every time you put skin care on, that skin microbiome you can't hear所以每次你把皮肤护理, 皮肤微生物,你听不到
117isn't going, nuclear bomb!核弹不会爆炸的!
118Now, by this time my son was 13, and he had acne.现在,这个时候我的儿子13, 他有疮。
119His pediatrician recommended benzoyl peroxide.他的儿科医生推荐过氧化苯甲酰.
120It's a very common and effective acne treatment.这是一种非常常见有效的疮道治疗.
121However, I was paranoid by this point.然而,在这一点上我偏执。
122And as a chemist, I knew that benzoyl peroxide was effective作为一个化学家,我知道过氧化苯甲酰是有效的
123because it's very reactive.因为它是非常被动的。
124But it also degrades into benzene, a known carcinogen.但也会降解成苯,一种已知的致癌物.
125And so I didn't buy it because you see in the United States it's available everywhere.所以我没有买它,因为你在美国看到它到处都有。
126In Europe it's refrigerated, but in the United States it's not,在欧洲,它是冷藏的, 但在美国,它不是,
127and I didn't trust the supply chain.我不信任供应链
128And so, guess what?所以,你猜怎么着?
129This October Yale University published a study on 111 benzoyl peroxide products这10月耶鲁大学发表了一项关于111 苯甲酰过氧化物产品的研究报告
130and found that 34% of them had benzene levels that exceeded the FDA safety limit,发现其中34%的苯含量超过了FDA的安全限值,
131some of them up to a factor of 12.其中一些高达12倍。
132The conclusion?结论?
133I think you can make that for yourselves.我想你们可以自己做
134And dermatologists in the US now are now reevaluating the use of this topical.现在美国皮肤科医生正在重新评价这个话题的使用。
135We had taken a different approach.我们采取了不同的做法。
136We went to clodosulfur, and sulfur basically is elemental.我们去了草原硫磺,硫磺基本上就是元素。
137It's part of our bodies.是我们身体的一部分。
138It's low risk.这是低风险。
139And we also called on European partners who could develop microbiome modulating systems我们还呼吁欧洲伙伴开发微生物体调制系统
140because ultimately acne is C-acne bacteria that overgrow your skin.因为最终的丙烯是C-acne细菌,它会过度扩大你的皮肤.
141So if you can shift the microbiome and rebalance it, you can get rid of acne.所以,如果你可以转移微生物体并重新平衡它,就可以去除ne.
142And we had 40% improvement, which was comparable to topicals that are commercially available,我们有40%的改进, 这与商业上的话题相当,
143but the acne kept coming back.但疮一直回来。
144And that's when we realized you have to treat it internally.那时我们意识到 你必须在内部治疗它。
145Oily skin, which is the breeding ground for acne bacteria, is caused by your gut,油性皮肤,是青霉菌的繁殖地, 是由你的肠道引起的,
146either inflammation or microbiome imbalance, or by your brain.要么是炎症 要么是微生物失衡 要么是你的大脑
147Cortisol, a stress hormone that unbalance your sex hormones.Cortisol 一种压力激素 让你的性激素无法平衡
148So we developed a probiotic herbal for common acne于是我们研制了一种普通青霉素的辅生药草
149and an ayurvedic herbal to rebalance hormones in female adult hormonal acne.和一种菊花草药 来重新平衡雌性成年激素的激素
150And the results matched conventional medicine.结果与传统医学相符。
15160% improvement in eight weeks.8周内改善60%
152So this was the first time we had real success with skin, gut, brain biome solutions.因此,这是我们第一次 在皮肤,肠道,大脑生物溶液方面 取得真正的成功。
153So we wondered if we could extend them to other things.因此,我们想知道,我们是否可以将它们扩大到其它方面。
154例如,eczema(英语:eczema).
155Well, the literature certainly seemed to point in that direction,文献似乎都指向这个方向
156but the pieces were there, but nobody had put them together.但碎片都在那里 但没人把它们拼凑在一起
157Now, eczema, traditionally dermatologists prescribe corticosteroids that have known side effects.现在,阴道瘤, 传统的皮肤科医生 开具皮质类固醇 已知的副作用。
158Skin thinning, porpoise, in children they can delay growth rates or cause Cushing syndrome.皮肤变薄,鼠海豚,在儿童中,它们可以延缓生长速度或引起库兴综合症.
159Worse yet, there's a group of people who get topical steroid withdrawal syndrome.更糟糕的是,有一群人 得了局部类固醇退缩综合症
160This is a violent immune reaction that happens suddenly这是突然发生的暴力免疫反应
161where their entire body is on fire and all of their skin peels.他们全身着火,皮肤被剥落
162Do we know why this happens?知道为什么吗?
163No.没有
164Do we know who's susceptible?我们知不知道谁容易感染?
165No.没有
166Can we do a lot better for everyone with eczema?我们可以做很多更好的 每个人的乳癌?
167Yes.对
168Now, eczema is an interesting skin-gut disease现在,风疹是一种有趣的皮肤病
169because both the skin barrier and the gut barrier are leaky.因为皮肤屏障和肠道屏障都漏水.
170That means they let pathogens and toxins into the body,这意味着他们让病原体和毒素进入身体,
171and that actually means that your body has an ongoing allergic reaction,这实际上意味着你的身体 持续过敏反应,
172bigger and bigger, which causes more and more inflammation.越大越多,引起越来越多的炎症.
173And today we still don't know if the leaky gut causes the leaky skin而今天我们仍不知道 漏泄的肠道是否引起 漏泄的皮肤
174or the leaky skin causes the leaky gut.或者皮肤漏泄导致肠道漏泄
175So we started on the inside this time.所以这次我们从内部开始
176文学将我们指向Elhistidine。
177It's an amino acid that is known by the body to rebuild a skin barrier是一种氨基酸,被身体称为重建皮肤屏障
178and has lessened eczema severity.并减轻了风疹的严重程度。
179We added to that a Patagonian antioxidant我们加了一种巴塔哥尼亚抗氧化剂
180that was known to reduce gut inflammation.这可以减少肠道炎
181Why?为什么?
182Well, many people with eczema have an inflamed gut.很多人患上风疹的肠胃炎
183We also created a probiotic.我们还创造了一种代生药。
184Why?为什么?
185Because people with eczema have a lower diversity gut microbiome,因为患风疹的人 具有较低的多样性 肠道微生,
186and in fact, many of them are lacking keystone species事实上,他们中有许多缺乏 关键物种
187like Bifidobacterium or Lactobacillus.就像细菌菌或乳房菌
188And in fact, we found that certain species of Lactobacillus事实上,我们发现 某些物种的乳房
189can reduce anxiety and depression.可以减少焦虑和抑郁症。
190Isn't that cool?这很酷吧?
191So we actually had an oral skin gut-brain biome solution.因此,我们实际上有一个口服皮肤肠道脑生物溶液。
192For the topical, we explored many different plants,对于话题,我们探索了许多不同的植物,
193and with genetic expression on human skin cells,人类皮肤细胞上的基因表达
194we isolated it to five plants whose cells could essentially我们把它隔离到五个植物中 它们的细胞基本上可以
195repair the skin barrier and reduce itch.修复皮肤屏障,减少痒。
196When we put it all together, in eight weeks,当我们把它拼凑在一起, 在8周内,
197we were shocked and our dermatologists were even more shocked.我们震惊了 我们的皮肤科医生更震惊
198Ninety-five percent eczema reduction in every single test patient每个测试病人的宫颈减少95%
199with mild to moderate atopic dermatitis.具有中度至中度的皮肤炎。
200This means we cleared the eczema.这意味着我们清理了阴道
201And that also meant that for the first time,这也意味着 第一次,
202there was a plant-based alternative integrative solution有一个基于工厂的替代综合解决方案
203available to challenge corticosteroids可用于挑战皮质类固醇
204for the first time in 70 years.这是70年来第一次
205So what does that mean?这是什么意思?
206Well, while much work remains to be done,虽然还有许多工作要做,
207I firmly believe that skin-gut-brain biome我坚信皮毛脑生物
208will represent and usher in a healthier future将代表并带来一个更健康的未来
209for the one billion people suffering from skin conditions10亿人的皮肤状况
210如ne,ec,s, and,ros.
211I also believe that in time, we will clinically prove我也相信,在时间,我们将临床证明
212that these integrative solutions are not only as effective这些综合解决办法不仅有效
213as conventional medicine, but have no side effects.作为常规医学,但无副作用。
214So to me, skin-gut-brain biome is the next revolution in medicine.因此,对我来说,皮毛脑生物是下一次医学革命。
215And what about all of you?你们呢?
216Well, you are the customer.你是顾客
217You can choose what you put in and out of your body.你可以选择你放进放出你的身体。
218You can prevent problems before they happen.在问题发生之前,你可以防止问题发生。
219And all of us together, by making the right decisions,我们大家通过做出正确的决定,
220we can transform industries.我们能改造工业。
221We can eliminate the bad things.我们可以消除坏事
222But as Seneca said, it is not because things are difficult但正如塞内卡所说 不是因为事情很困难
223that we do not dare.我们不敢。
224It is because we do not dare.这是因为我们不敢。
225They are difficult.他们是困难的。
226So I challenge all of you.我挑战你们所有人
227Dare, think, read, learn, question.敢,思,读,学,问.
228Knowledge is power, so be informed, not influenced.知识是力量,所以要知情,不要受到影响.
229To me, this journey started with my son's allergy.对我来说,这段旅程始于我儿子的过敏.
230And I'm now developing integrative solutions我现在正在开发综合解决方案
231that I hope will ease unnecessary suffering.我希望能够减轻不必要的痛苦。
232For you, the questions will be different.对你来说,问题不同
233But your journey of discovery, no less transformative.但你的发现之旅, 并非不亚于变革。
234So join me in changing the world,跟我一起改变世界
235one skin-gut-brain biome at a time,一次一个皮肤大脑的生物化石,
236because this is metamorphosis.因为这是变形。
237Thank you.谢谢
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