打造无瑕年轻肌肤的5大科学依据补剂｜Andrew Huber
字幕摘录
| 时间 | 英文 | 中文 |
|---|---|---|
| 0:00 | Let's talk about youthfulness of skin or the appearance of youthfulness in skin, what to do, | 让我们来谈谈皮肤的青春 或皮肤的青春,怎么办, |
| 0:05 | what to buy or not buy as the case may be to try and reverse aging or the appearance of aging in | 购买或不购买什么 可能的情况是尝试 扭转老化或老化的出现 |
| 0:12 | skin or even create de novo new synthesis of collagen and skin to make skin look more youthful. | 皮肤,甚至创造新合成的 胆固醇和皮肤 使皮肤看起来更年轻。 |
| 0:22 | Let's talk about where there is a lot of evidence for certain things that you can do if your goal | 我们来谈谈 哪里有很多证据可以证明某些事情 如果你的目标 |
| 0:27 | is to increase the youthfulness or the appearance of youthfulness in your skin. | 就是增加你皮肤中的青春度或青春度 |
| 0:30 | And one of the main | 还有一个主 |
| 0:31 | ones is collagen itself. | 一种是碳氢化合物本身。 |
| 0:33 | As you know, there are various macronutrients present in foods. | 如你所知,食物中含有各种宏观营养物质。 |
| 0:36 | You can | 你当然可以 |
| 0:36 | have proteins, fats, and carbohydrates. | 有蛋白质、脂肪和碳水化合物。 |
展开字幕全文（217 条）
| 序号 | 英文 | 中文 |
|---|---|---|
| 1 | Let's talk about youthfulness of skin or the appearance of youthfulness in skin, what to do, | 让我们来谈谈皮肤的青春 或皮肤的青春,怎么办, |
| 2 | what to buy or not buy as the case may be to try and reverse aging or the appearance of aging in | 购买或不购买什么 可能的情况是尝试 扭转老化或老化的出现 |
| 3 | skin or even create de novo new synthesis of collagen and skin to make skin look more youthful. | 皮肤,甚至创造新合成的 胆固醇和皮肤 使皮肤看起来更年轻。 |
| 4 | Let's talk about where there is a lot of evidence for certain things that you can do if your goal | 我们来谈谈 哪里有很多证据可以证明某些事情 如果你的目标 |
| 5 | is to increase the youthfulness or the appearance of youthfulness in your skin. | 就是增加你皮肤中的青春度或青春度 |
| 6 | And one of the main | 还有一个主 |
| 7 | ones is collagen itself. | 一种是碳氢化合物本身。 |
| 8 | As you know, there are various macronutrients present in foods. | 如你所知,食物中含有各种宏观营养物质。 |
| 9 | You can | 你当然可以 |
| 10 | have proteins, fats, and carbohydrates. | 有蛋白质、脂肪和碳水化合物。 |
| 11 | When we ingest proteins, such as beef, chicken, fish, | 当我们摄入蛋白质,如牛肉,鸡,鱼, |
| 12 | eggs, they contain different amounts of different essential amino acids. | 蛋,它们含有不同量的不同的基本氨基酸. |
| 13 | And those essential amino | 和那些基本的氨基 |
| 14 | acids are used as the building blocks for proteins in our muscles, in our tendons, | 酸被作为蛋白质在肌肉, 我们的阴茎, |
| 15 | in essentially all the organ systems of our body. | 基本上我们身体的所有器官系统。 |
| 16 | What most people in the field of nutrition agree | 营养领域的大多数人都同意 |
| 17 | upon and what certainly I believe is that if you were to say, eat a little bit of liver, right? | 我相信 如果你要说 吃一点肝脏 对吗? |
| 18 | You | 你们 |
| 19 | might have a little bit of cooked liver that there's no selective trafficking of the amino | 可能有一点点煮的肝脏 没有选择性贩运氨基 |
| 20 | acids that are broken down from the liver that you eat to your liver. | 从你吃的肝脏分解到肝脏的酸。 |
| 21 | However, when we talk about | 然而,当我们谈论 |
| 22 | collagen, this protein that forms one of the most essential aspects of what makes our skin what it | 这个蛋白质 是我们皮肤中最重要的一个方面 |
| 23 | is, which is elastic. | 这是弹性的。 |
| 24 | Why would ingesting collagen be selectively trafficked to the collagen in our | 为什么要有选择地把摄入的 col 贩运到我们的 col中 |
| 25 | skin? | 皮肤? |
| 26 | That doesn't square with everything we know. | 这和我们所知的不一样 |
| 27 | And yet when you look at studies, | 然而当你看着学习, |
| 28 | including meta-analyses of studies where people supplement with collagen powders, | 包括研究的元分析,其中人们用焦糖粉补充, |
| 29 | and these powders typically come from fish or tendon, any number of different sources, | 这些粉末一般来自鱼或on, 任何数量的不同来源, |
| 30 | you often will find studies that show statistically significant improvements | 通常您会发现在统计学上有显著改进的研究 |
| 31 | in collagen composition and skin appearance, and even the appearance of reduction in wrinkles | 连皱纹减少的外观 |
| 32 | and so forth. | 诸如来. |
| 33 | So this is an interesting exception where the ingestion of a particular protein | 因此,这是一个有趣的例外, 其中摄入特定的蛋白质 |
| 34 | that naturally exists in abundance in certain tissues, such as skin, but also other tissues | 自然存在于某些组织中的丰度,例如皮肤,但也存在于其他组织中。 |
| 35 | like tendon, ligaments, et cetera, seems to be assisting in either the repair and rejuvenation | 像是手势、韧带等 有助于修复和复兴 |
| 36 | of collagen or perhaps some other aspect of collagen synthesis that leads to improvements | 化合物合成中可导致改进的 |
| 37 | in collagen composition and the appearance of skin in humans. | 和人类皮肤的外观 |
| 38 | The basic takeaway of this | 基本吃这个 |
| 39 | and other meta-analyses is that when people supplement with anywhere from five to 15 grams, | 而其他元分析是 当人们用5克到15克来补充时 |
| 40 | okay, grams, of hydrolyzed collagen per day, in particular in combination with vitamin C, | 好吧,克,每天水解焦糖, 特别是结合维生素C, |
| 41 | it doesn't have to be a lot of vitamin C, that one can observe, okay, not always, | 不需要很多维生素C, 人们可以观察, 好吧,并不总是, |
| 42 | but can observe some visible improvements in skin composition, meaning less wrinkles, | 但可以观察到皮肤成分的明显改善, 意思是减少皱纹, |
| 43 | even some reversal of wrinkles, less skin sagging, more youthful appearance, more, | 连皱纹的反转 少了皮肤的皱纹 更年轻些的外表 更多 |
| 44 | let's just call it, rebound elasticity of the skin. | 就叫它 皮肤的弹性 |
| 45 | I realize that's not the appropriate | 我知道这不合适 |
| 46 | technical term, but the ability of a skin to bounce back from an indentation when you push | 技术术语,但皮肤的回弹能力 从缩进 当你推 |
| 47 | down on it, as opposed to saying down or sagging. | 而不是低调或低调 |
| 48 | So some pretty impressive results when one | 所以,一些相当令人印象深刻的结果 当一个 |
| 49 | considers that what people are basically doing here is just mixing up some hydrolyzed collagen | 认为人们基本上在这里所做的只是 混合一些水解的焦糖 |
| 50 | protein and then drinking that down once per day or so. | 蛋白质,然后每天喝一次 |
| 51 | Now that is not to say that you have to | 这并不是说你必须 |
| 52 | supplement with hydrolyzed collagen. | 补充水解的碳酸盐。 |
| 53 | Why? | 为什么? |
| 54 | Well, collagen is also present in various foods. | 各种食物中也含有氯拉根 |
| 55 | So | 这么说 |
| 56 | for instance, drinking bone broth, beef bone broth, chicken bone broth is a rich source of | 例如,饮用骨肉汤,牛肉骨肉汤,鸡肉骨肉汤是丰富的来源. |
| 57 | collagen. | 高尔拉根。 |
| 58 | You can go online and simply look up just by web search. | 你可以上网,只要通过网络搜索就可以了。 |
| 59 | You can just say, you know, | 你可以说,你知道, |
| 60 | what foods contain high levels of collagen, and you'll get a list of things back there. | 食物中含有高含量的碳酸盐 后面就会有一份清单 |
| 61 | Hopefully, | 希望这样 |
| 62 | a few of those are not just palatable to you, but you actually like, and you can start to include | 有一些不只是你喜欢的, 但你实际上喜欢, 你可以开始包括 |
| 63 | those in your daily diet, or you could supplement with hydrolyzed collagen protein. | 或者你可以补充水解的碳糖蛋白 |
| 64 | There are any | 这儿有的 |
| 65 | number of different sources for these. | 数字。 |
| 66 | For those of you that are interested in ingesting collagen | 给那些对摄取高拉根感兴趣的人 |
| 67 | peptides as a way to improve the youthfulness of your skin, should mention that the dosages there | 作为提高皮肤年轻度的一种方法, peptides, 应该提到那里的剂量 |
| 68 | come in a range, depending on the studies that you've looked at. | 根据你所看的研究 来一个范围。 |
| 69 | And the dermatologist that I | 而皮肤科医生,我 |
| 70 | spoke to said, if one decides to go down this route of supplementing or getting collagen from | 如果有人决定沿着这条路线去补充或从 |
| 71 | food sources, you want to aim for anywhere from 15 grams to 30 grams of collagen peptides per day. | 食物来源,你想瞄准的任何地方 从每天15克到30克的collagen peptides。 |
| 72 | Okay. | 摆 |
| 73 | That's a bit higher than what was used in a number of studies, but you'll find studies that | 这比很多研究中使用的要高一点 但你会发现 |
| 74 | use 30 grams and that that whole process can be augmented, can be improved through ingestion of | 通过摄入可改进整个过程。 |
| 75 | 500 to a thousand milligrams of vitamin C as well. | 500至1000毫克的维生素C也一样. |
| 76 | But check the label on those collagen peptides | 但检查这些胶原的标签 |
| 77 | that you might be supplementing with, because oftentimes they already include that 500 to a | 你可能正在补充, 因为经常他们已经包括500到1 |
| 78 | thousand milligrams of vitamin C. What about other peptides? | 一千毫克维他命C 其他的镇痛剂呢? |
| 79 | Okay. | 摆 |
| 80 | So this is a big topic nowadays, | 所以现在这个话题很重要 |
| 81 | especially in the online communities. | 特别是在网络社区。 |
| 82 | There are lots of things that qualify as peptides, but these | 有很多东西 符合 peptides , 但是这些 |
| 83 | when you hear about quote unquote peptides, especially in online communities, generally | 当你听到引文未引用的peptides, 特别是在在线社区, |
| 84 | people are referring to exogenously given. | 人们指的是外在给予。 |
| 85 | So pills, ointments, or more typically injections | 所以,药片,药膏, 或更典型的注射 |
| 86 | of peptides that are designed to achieve some specific biological or physiological outcome. | 用于实现某种特定生物或生理结果的肽。 |
| 87 | And one of the more common of these peptides being used nowadays is one that I've talked about before | 其中一个比较常见的这些药剂 现在被使用的是 我之前说过的 |
| 88 | called BPC 157 body protection compound 157. | 称为BPC 157 尸体保护复合物 157。 |
| 89 | It's known that certain peptides within the gut that | 众所周知 肠道里的某些脓肿 |
| 90 | is known to mimic can assist in tissue and wound repair of different kinds, tendon, anything | 已知可以模仿不同种类的组织和伤口修补, |
| 91 | involving fibroblasts. | 涉及纤维爆炸。 |
| 92 | All of that has been well demonstrated in vitro in a dish. | 所有这一切都在试管中得到了很好的证明。 |
| 93 | Okay. | 摆 |
| 94 | So not in | 所以不要进去 |
| 95 | vivo as well as in vivo in certain cases, but only in animal models. | 在某些情况下是活体和活体,但只在动物模型中。 |
| 96 | To my knowledge, there's | 据我所知,有 |
| 97 | only one study and frankly, it's not a very good study at all on BPC 157 in humans. | 只有一项研究,坦率地说,它对于人类的BPC 157研究完全不是很好. |
| 98 | And yet a lot | 但还是很多 |
| 99 | of people are taking BPC 157 either orally in the form of a capsule or pill or more typically | 以胶囊或药丸的形式口服或更典型的 |
| 100 | injecting it. | 注射过 |
| 101 | What does it do or what does it likely do in humans? | 它在人类身上会做什么? |
| 102 | We know from animal models | 我们从动物模型中知道 |
| 103 | that BPC 157 increases angiogenesis, the growth of capillaries and blood vessels. | BPC157会增加血管增生 增加卷毛和血管增生 |
| 104 | We know this. | 我们知道这一点。 |
| 105 | It can accelerate wound healing by virtue of increasing fibroblast motility. | 它可以通过增加纤维弹性来加速伤口愈合. |
| 106 | For this reason, | 为此, |
| 107 | it's used post injury in sports. | 后伤用于运动。 |
| 108 | It's used by people who want to build more muscle. | 是为欲造多肌肉者用. |
| 109 | It's used | 已经用了 |
| 110 | by endurance athletes. | 由耐力运动员。 |
| 111 | It's used for cosmetic purposes. | 用于化妆品用途. |
| 112 | Anytime people are using BPC 157, | 无论何时人们使用BPC 157, |
| 113 | for any of those purposes, it's likely that they're using it in part to increase the blood | 为了这些目的 他们很可能是用它来增加血液 |
| 114 | flow that's available to a given tissue and the repair of that tissue. | 流到一个特定的组织 和修复那个组织。 |
| 115 | Now, again, I do want to | 现在,再次,我想 |
| 116 | caution people that there is very little, basically no evidence in humans besides the anecdotal | 提醒人们除了传闻外 人类几乎没有证据 |
| 117 | evidence that people say they healed faster. | 有证据表明人们说他们愈合得更快。 |
| 118 | What I do know is that anytime you get vascularization | 我所知道的是,无论何时 你得到血管化 |
| 119 | of tissue, you're going to get improved blood flow. | 组织,你会得到改善的血液流动。 |
| 120 | So it all makes sense mechanistically. | 所以从机械角度来说都是有道理的. |
| 121 | I also know that vascularization due to BPC 157 is likely to occur globally throughout the body. | 我还知道,由于BPC 157引起的血管化可能在全球范围内发生。 |
| 122 | That also tells us that there's going to be increased vascularization of other tissues, | 这也告诉我们 其它组织的血管化会增加 |
| 123 | such as skin, such as tumors, if tumors exist. | 如皮肤,如肿瘤,如果肿瘤存在. |
| 124 | So you need to be very careful. | 所以,你需要非常谨慎。 |
| 125 | I need to say | 我得说 |
| 126 | that upfront as a cautionary note, more and more products are out there that contain BPC 157. | 更多含有BPC 157的产品 |
| 127 | I can't in good conscious recommend those products. | 我无法有意识地推荐这些产品。 |
| 128 | I can only offer to you the likely mechanism by | 我只能通过 |
| 129 | which they work. | 他们的工作。 |
| 130 | If they work, the logic would be that if you take a cream containing BPC 157, | 如果有用的话 逻辑是 如果你服用含BPC 157的奶油 |
| 131 | and you put it on there, that you'll get increased vascularization of that area, | 你把它放在那里, 你会得到增加的血管 该地区, |
| 132 | delivery of more growth factors and nutrients, and those wrinkles will either be halted in their | 提供更多的生长因素和营养物质,这些皱纹要么会停止。 |
| 133 | aging progression or that they will reverse. | 衰老或逆转。 |
| 134 | That's the logic. | 这就是逻辑 |
| 135 | Many of the products that contain | 许多产品含有: |
| 136 | BPC 157, by the way, also contain copper. | 顺便说一句,BPC 157也含有铜. |
| 137 | Copper is a trace mineral. | 铜是一种微量矿物. |
| 138 | It's found in your diet. | 在你的饮食中发现。 |
| 139 | There is some evidence that copper is important for some of the collagen and other elements of | 有一些证据表明,铜对于其中的一些碳化物和其他元素很重要。 |
| 140 | skin synthesis pathways. | 皮肤合成途径. |
| 141 | And so the mechanistic logic and the biochemical logic is there on paper. | 因此,机械逻辑和生化逻辑在纸面上。 |
| 142 | Copper has been shown to play a key role in DNA repair, which is a critical component of the | 事实证明,铜在DNA修复中发挥着关键作用,而DNA修复是其中的一个关键组成部分。 |
| 143 | turnover of collagen and other proteins in skin. | 皮肤中的甲状腺素和其他蛋白质的转化. |
| 144 | It has been shown to reduce so-called reactive | 事实证明,它减少了所谓的被动反应。 |
| 145 | oxygen species. | 氧气种类。 |
| 146 | So it serves as a so-called antioxidant, but too much copper is a problem. | 所以它是一种所谓的抗氧化剂,但是太多的铜是一个问题. |
| 147 | So I wouldn't run out and start supplementing with excessive amounts of copper. | 所以我不会耗尽 并开始补充 过多的铜。 |
| 148 | Please don't | 请不要 |
| 149 | do that. | 做到这一点。 |
| 150 | But you want to make sure that you're getting sufficient amounts of copper from your | 但你要确保你从你的铜矿里 得到足够的铜矿 |
| 151 | diet. | 饮食. |
| 152 | And you can simply look up online what sufficient amounts of copper are, given it's | 你可以上网查一下 足够多的铜 |
| 153 | trace mineral. | 追踪矿物。 |
| 154 | And it's very likely that if you ingest any kind of supplement that is a multi | 如果你摄入任何一种补充物 很可能是多种 |
| 155 | vitamin mineral supplement or a foundational nutrition supplement, that includes at least | 维生素矿物质补充或基本营养补充,至少包括: |
| 156 | some copper. | 一些铜。 |
| 157 | So it's likely that you're sort of quote unquote topped off in terms of the amount | 所以,你可能有点 引出未引号的金额 |
| 158 | of copper that you need, but very unlikely to be excessive amounts of copper. | 铜,但不太可能是过多的铜。 |
| 159 | But if you start | 但是如果你开始 |
| 160 | supplementing with copper beyond that, again, you can induce an inflammatory response. | 再用铜来补充 也可以引起炎症反应 |
| 161 | So | 这么说 |
| 162 | it's a dosage kind of middle ground issue there. | 这是一种剂量类型 中间地面问题在那里。 |
| 163 | You don't want your copper too low. | 你不希望你的铜太低。 |
| 164 | You don't want | 你不会想要的 |
| 165 | copper too high. | 铜太高. |
| 166 | You want it right there in the middle. | 你想要它就在中间 |
| 167 | So when I spoke to board certified | 所以当我和董事会交谈时 |
| 168 | dermatologists, what people can do to improve the youthfulness or the appearance of youthfulness in | 皮肤科医生,人们可以做些什么 来提高年轻人的青春度或年轻人的外表 |
| 169 | their skin, they mentioned supplementing with niacinamide. | 他们提到用硝胺来补充皮肤 |
| 170 | Niacinamide是一种维生素B3. | |
| 171 | It is also sometimes referred to as nicotinamide. | 它有时也被称为尼科蒂纳酰胺. |
| 172 | And I was told that when taken at twice per day | 我被告知,当每天两次拍摄 |
| 173 | at a dosage of 500 milligrams per dose for a total of one gram or 1000 milligrams per day, | 剂量为每剂500毫克,每天总计1克或1,000毫克, |
| 174 | that niacinamide supplementation can increase the production of ceramides, which relate to | 氮化物补充剂可以增加丙氨酸的产量,这与 |
| 175 | the lipids in skin that improve the moisture in skin. | 皮肤中的脂质能改善皮肤中的水分 |
| 176 | And by the way, moisture in skin is a key | 顺便说一句 皮肤中的水分是关键 |
| 177 | component of the youthfulness or plump appearance of that skin. | 年轻或高耸的外表 |
| 178 | And when I say plump, I don't | 当我说羽毛,我不 |
| 179 | necessarily mean outwardly rounded plump. | 必然是指外圆形的羽毛. |
| 180 | I mean the fact that the skin looks like the outermost | 我的意思是,事实上,皮肤看起来像最外层 |
| 181 | layer of the skin, which you now know as the epidermis is kind of taut and the skin looks | 皮肤的一层,你现在知道 作为表层 有点俗气,皮肤看起来 |
| 182 | and smooth at the level of its outer appearance. | 并保持外表的光滑。 |
| 183 | All of that is improved by niacinamide | 所有这一切都通过硝基南化得到改进 |
| 184 | supplementation, but that the supplementation has to be carried out for three to six months or more | 补充,但补充必须进行3至6个月以上 |
| 185 | before that effect is noticed. | 在注意到这种效果之前。 |
| 186 | Now, the origin of the niacinamide effect on the youthfulness of skin | 现在,硝基纳米化物的起源 对皮肤年轻化的影响 |
| 187 | could also be related to the fact that there's evidence that niacinamide supplementation can | 也可能与有证据表明氮化物补充物可以 |
| 188 | reduce inflammation of skin overall. | 总体减少皮肤炎症。 |
| 189 | We haven't talked so much about the immune skin relationship, | 我们没怎么谈论免疫性皮肤关系 |
| 190 | but for those of you suffering from rosacea, from acne, niacinamide supplementation may also | 但是对于那些患有罗萨西亚病的人, 以及患有青霉素, 硝酸亚胺补充剂的人来说, |
| 191 | assist there. | 协助那里。 |
| 192 | Regardless of whether or not you suffer from rosacea, acne, or not at all, | 无论你是否患上罗萨西亚,青霉素,还是完全没有 |
| 193 | niacinamide supplementation may benefit you. | 氮化物补充剂对你有好处 |
| 194 | Also, because niacinamide supplementation appears to | 另外,因为硝胺补充剂似乎 |
| 195 | balance the level of oil production in the skin, you need oil in the skin, you need oil down in | 平衡皮肤中的石油产量, 你需要皮肤中的石油, 您需要石油 |
| 196 | those pores, but not too much. | 那些毛孔,但不会太多。 |
| 197 | And it can definitely help reduce the appearance of clogged pores. | 它肯定可以帮助减少 堵塞的毛孔的外观。 |
| 198 | And if you're concerned about pores that appear too large, this typically happens in the face, | 如果你担心 毛孔看起来太大, 这通常发生在脸上, |
| 199 | around the nose, on the upper cheeks, although other regions of the body as well, niacinamide | 鼻部,上颊部,虽然身体的其他地区, 以及硝化ide |
| 200 | supplementation may assist with that as well. | 补充也可有助于实现这一目标。 |
| 201 | There's also a number of people out there that | 外面还有很多人 |
| 202 | are concerned with specific spots that they see as hyperpigmented spots. | 关注他们视其为超溢出斑点的特定斑点。 |
| 203 | So regardless of whether | 所以,无论 |
| 204 | or not overall your skin is very light or very heavily pigmented, supplementation with niacinamide | 或整体上,你的皮肤非常浅或非常浓厚的颜料,用硝酸ide来补充 |
| 205 | can reduce the appearance of accumulation and maybe even the actual accumulation of melanin | 能够减少聚氨酯的出现 甚至可能减少聚氨酯的实际积累 |
| 206 | at particular spots, so-called dark pigmented spots that some people decide that they don't | 在特定的斑点,所谓的暗色斑点 有些人决定他们不 |
| 207 | for whatever reason, usually just cosmetic reasons. | 无论出于什么原因, 通常只是表面的原因。 |
| 208 | Now, if you decide to supplement | 现在,如果你决定补充 |
| 209 | with niacinamide, you have the option of either taking that thousand milligrams and two 500 | 用硝胺,你要么选择 要么拿那一千毫克和两500 |
| 210 | milligram dosages per day. | 每日用毫克剂量。 |
| 211 | You also have the option of using any number of different topical | 您也可以选择使用任意数量的不同主题 |
| 212 | niacinamide ointments or serums that exist out there. | 存在于外面的硝胺膏或血清 |
| 213 | Keep in mind that many skincare | 记住很多的护肤 |
| 214 | products already contain niacinamide, so check the label. | 产品中已经含有硝胺, 请检查标签。 |
| 215 | And there the dermatologists tell me | 皮肤科医生告诉我 |
| 216 | that to be effective, the niacinamide needs to be present at at least a two and as high as 10% | 氮化物必须至少存在2个且最高达10%才能有效。 |
| 217 | concentration within those ointments or serums. | 这些药膏或血清中的浓度。 |
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