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呼吁研究者高度重视：癌症治疗与预防突破性发现，大多数人都不知

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时间英文中文
0:00They were there because of circumstance.他们在那里是因为情况。
0:03And we learned Paleolithic man was always in some sort of a state of some ketosis because我们了解到旧石器时代的人 总是处于某种状态 一些基特化,因为
0:09they wouldn't have food for periods.他们不会有食物一段时间。
0:11They were very active in their exercise.他们非常积极地进行演习。
0:14They didn't have chronic diseases, but they had other kinds of diseases.他们没有慢性病,但他们有其他类型的疾病.
0:18So then my students, Derek Lee, myself, and Christos Shinopoulos, we started to make a然后,我的学生,德里克・李,我自己,和克里斯托斯・希诺普洛斯, 我们开始做一个
0:26ratio chart.比率图表。
0:27Now, these are the numbers that you get when you divide your sugar by your ketones.现在,这是你得到的数字 当你的糖 与你的酮。
0:32OK, so my sugar by my ketones.好吧,所以我的糖在我的酮。
0:33So if I did my glucose measure now on this little really here.所以,如果我做了我的葡萄糖措施 现在在这个小 真正在这里。
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序号英文中文
1They were there because of circumstance.他们在那里是因为情况。
2And we learned Paleolithic man was always in some sort of a state of some ketosis because我们了解到旧石器时代的人 总是处于某种状态 一些基特化,因为
3they wouldn't have food for periods.他们不会有食物一段时间。
4They were very active in their exercise.他们非常积极地进行演习。
5They didn't have chronic diseases, but they had other kinds of diseases.他们没有慢性病,但他们有其他类型的疾病.
6So then my students, Derek Lee, myself, and Christos Shinopoulos, we started to make a然后,我的学生,德里克・李,我自己,和克里斯托斯・希诺普洛斯, 我们开始做一个
7ratio chart.比率图表。
8Now, these are the numbers that you get when you divide your sugar by your ketones.现在,这是你得到的数字 当你的糖 与你的酮。
9OK, so my sugar by my ketones.好吧,所以我的糖在我的酮。
10So if I did my glucose measure now on this little really here.所以,如果我做了我的葡萄糖措施 现在在这个小 真正在这里。
11Let's see what your GKI is.让我们看看你的GKI是什么。
12Oh, you want me to do it?哦,你想我做到这一点?
13OK.摆
14OK, what you had a glucose, you had a ketone with 0.4 millimolar.好吧,你有一个葡萄糖, 你有一个酮 0.4毫莫拉。
15Yeah.对
16OK, what was your sugar?好吧,什么是你的糖吗?
17So we can divide, we can do the division right now and tell you what you have.这样我们就可以分头行动,我们现在就可以完成组织的任务,并告诉你所拥有的一切.
18You can get these little ketones.你可以得到这些小酮。
19哦,是的,这是一个keto mojo。
20And you can also get them now for for.你现在也可以买到
21Wow, these guys are skilled at doing this.哇,这些家伙很能干
22I travel with one of these, believe it or not.我带着这个旅行 信不信由你
23Yeah.对
24So I have one all the time.所以我一直有一个。
25Well, 90, 90.嗯,90,90个。
26OK, so you have to you have to divide.好吧,所以你必须分裂。
27You have to divide.须分身.
28You're not getting it.你不会明白的
29Doesn't this give you the push button to give the GKI right away?这难道不给你一个按键 立刻给GKI吗?
30Because the new ones have it.因为新来的有它。
31So you have to divide 90 by 18 and you get a number five, five.所以你得把90除以18 然后得到5,5
32So divide five by zero point four, twelve point five.所以以零点四除五,十二点五.
33OK, so here you are.好吧,你在这里。
34Twelve point five.十二点五分
35You're down here in the in the in the prevention zone.你在预防区内
36OK, so so you this is where Paleolithic Man mostly lived.好了,所以你这里是旧石器人的主要生活。
37Paleolithic Man lived in the yellow green zones旧石器人住在黄绿区
38because they didn't have access to all of the things因为他们不能接触所有的东西
39that would drive up your blood sugar and keep your key.那会把血糖推高,把钥匙留着
40When your blood sugar goes through the roof, your ketones are really low当你的血糖通过屋顶, 你的酮真的很低
41because insulin is now driving it up.因为胰岛素正在推动它的发展
42So so that's good.所以这是很好的。
43Twelve.十二个
44So I did the I did the carnivore diet for a week.所以我做了一周的食肉饮食。
45Eating big rib eyes.饮食大肋眼.
46You like rib eye steak?你喜欢肋眼牛排吗?
47Yes, of course.当然
48OK, rib eyes, bacon and eggs, lamb.好吧,肋骨眼,培根和鸡蛋,羊肉。
49So I did it for a week and I was able to get down to 10.所以我做了一个星期,我能够降到10岁。
50OK, and I could get lower, but I was loving the rib eye so much.好吧,我可以低调, 但我很喜欢肋眼。
51I ate too much of it, right?我吃太多了,对不对?
52You have to have some level of discipline.你必须有一定程度的纪律。
53So so so but people people.所以是这样,但人。
54This is what we call the zone of prevention.这就是我们所说的预防区。
55It's very hard to get cancer or chronic diseases很难得癌症或慢性病
56when you're in these zones当你在这些区域
57because you're keeping this organelle quite healthy.因为你保持这个风琴 相当健康。
58When you live in these zones consistently.当你一直生活在这些区域。
59You don't have to live consistently because humans你不必因为人类而一直活下去
60we evolved as a scavenger species.我们演化成一个拾荒物种。
61Yeah, we would engorge ourselves because we knew it wasn't happening every day.是的,我们会凝结自己,因为我们知道 这不是每天都发生。
62Modern man is living in the feast every single day.现代人每天都在宴会上生活.
63And that's why we're we're now all the chronic diseases.所以现在我们都是慢性病
64This is the red zone is the zone of risk红区就是危险区
65for chronic diseases and cancer.慢性病和癌症。
66And when you look at the obesity epidemic, you look at all these things.当你看肥胖症时,你就会看所有这些事情。
67These guys are and it's like we can visit the red zone.这些家伙是,它就像我们可以访问红区。
68We don't want to live in the red zone.我们不想住在红区
69So if I was to visit the red zone, it would look like meeting所以如果我去红区,那就好像见面一样
70high carbohydrate diets, lots of sugar.高碳水化合物饮食,多糖.
71Yeah.对
72No exercise.没有锻炼。
73Exercise.运动
74Yeah.对
75And basically modern man and also eating five meals a day,基本上现代人 每天吃五顿饭
76like snacking all the time.喜欢吃零食所有的时间。
77Yeah.对
78Oh, then you'd be you know, we have this document cases.哦,那么你会知道, 我们有文件箱。
79We have them up to five hundred.我们有500个
80You're joking.你在开玩笑吧
81Yeah.对
82GK eyes are five hundred.GK眼睛有五百个
83You have people with, you know, blood sugars about four or five血糖大概有四五颗
84hundred milligram per deciliter.每升100毫克.
85I mean, you could do the zero ketones.我的意思是,你可以做零酮。
86I mean, you do that.我的意思是,你这样做。
87You do the math.你做数学。
88It's unbelievable.难以置信
89You're basically saying I want to keep my my blood glucose levels.你是说我想保持我的血糖水平
90And you want to you want to have some level of ketones你想吃点酮吗?
91and heart and my ketone levels somewhat as high as I can.心脏和我的酮含量 尽可能高
92Well, you don't want to go because people don't hear the physicians你不想去,因为人们听不见医生
93听着,哦,他会去 ketoacidosis。
94People give me a break.众生饶我.
95Ketoacidosis is like when you have ketone levels of 15 to 20 millimolar.Ketoacidosis 就像你体内的酮含量 是15到20毫摩尔
96Are you kidding me?你在开玩笑吧?
97What is your zero point four?你的零点四分是多少?
98That's called nutritional ketosis.这叫营养性酮化
99That's how we evolved.这就是我们进化的方式。
100When you have type one diabetes where you can't control sugar or or or insulin,当你患上一类糖尿病 无法控制糖或胰岛素时
101you have no insulin responsive.你没有胰岛素反应
102You're going to get high levels of sugar and ketones.你会得到高浓度的糖和酮。
103This is this is a pathological condition.这是病理状况
104Most of type two diabetes, these are all pathologies大多数2型糖尿病都是病变
105based on damaging oxidative phosphorylation.以破坏性氧化性磷酸盐为基础。
106So what this chart does is for the first time and we put it together所以这个图表是第一次 我们把它拼在一起
107because we did all the in the paper discusses the bioenergetics.因为我们在报纸上都讨论过生物能量
108What we're finding in cancer is that if you can get into the green zones我们在癌症中发现的是 如果你能进入绿色区域
109where your blood sugar is low and your ketones are elevated,在你的血糖低 和你的酮升高,
110you hammer the hell out of these tumor cells because they they they你用锤子击出这些肿瘤细胞 因为他们
111you're taking away one of their two primary fuels你要拿走他们两个主要燃料之一
112driving dysregulated cell growth.驱动抑制细胞生长。
113OK. And as the and as the and as the ketones go up,摆 随着酮的升华
114the rest of your cells in the body are getting super healthy.身体里的其他细胞都变得非常健康
115The tumor cells can't tap into the value of a ketone肿瘤细胞无法进入酮的值
116because the organelle needed in the tumor cell to do that is corrupted因为肿瘤细胞中需要的管风琴被腐蚀
117structurally and functionally.结构与功能.
118Is am I clear about that?我说清楚了吗?
119Yes.对
120OK.摆
121So ketones will make you healthy,所以酮会让你健康
122the normal cells of your body, but cannot be used to help the cancer cell身体正常细胞,但不能用来帮助癌细胞
123because you need a good structural functional organelle to burn them.因为你需要一个良好的结构功能 风琴来燃烧它们。
124So they become marginalized.因此,他们变得被边缘化。
125And if the ketones go up, they're actually toxic to that to that cell如果酮类上升,它们实际上对细胞有毒
126to some extent.在某种程度上。
127So but they're still alive.但他们还活着
128The cancer cells are now incapacitated.癌细胞现已丧失能力。
129They're we showed you get rid of the abnormal inflammation.我们让你摆脱异常炎症
130You get rid of the angiogenesis, the abnormal blood vessels.你摆脱血管瘤 异常血管
131You're taking an angry tumor and making it much less angry,你拿一个愤怒的肿瘤 并让它少得多愤怒,
132much less inflamed, more indolent kind of a tumor.少得多的发烧, 更不耐烦的肿瘤。
133But it's still there.却还在那里.
134It's not because the other fuel that's keeping this cancer cell不是因为其他燃料 保持这个癌细胞
135going is the glutamine.是谷氨酸
136OK, so now when you have the patient好吧,现在,当你有病人
137in this green zone, this is for management now.在这个绿色地带, 这是管理层现在。
138Steven, this is prevention is is never having to deal史蒂芬,这是预防 从来不需要处理
139with what I'm talking about.和我说的一样
140If you're living in the yellow zone, the probability of getting cancer如果你住在黄区,癌症的概率
141or chronic diseases is already reduced.或慢性病已经减少。
142OK, but now you have some poor guy out there.好吧,但现在你有 一些可怜的家伙在那里。
143He's living in the red zone his whole life.他一辈子都住在红区
144He wants to manage the cancer that he has.他想管理他的癌症。
145He has to get down in the green zone and try to stay there as long as he can.他必须下到绿区 并尽量在那里停留。
146But the cancer will still grow because it has access to glutamine.但癌症仍然会增加 因为它可以得到谷氨酸。
147OK, and glutamine is always here's the bloodstream.好吧,谷氨酸总是在这里的血液。
148Look, you have this much blood cancer needs that.你看,你有这么多 血癌需要。
149So you always have a surfeit of glutamine.所以,你总是有一个冲浪 谷氨酸。
150So you have to come in now with drugs and the drugs like repurposed drugs所以,你现在必须进来 药物和药物 像重新使用药物
151to target the glutaminolysis with this one here, this BMC big paper here.将重度氨基解析作为目标 用这个,这个BMC的大纸在这里。
152OK, this paper and the new one we have with the ketogenic好吧,这张纸和我们的新纸 与ketogenic
153for the childhood high grade glioma for kids.儿童高年级胶片
154So once once you get down here,所以一旦你到了这里,
155you come in with drugs that target glutamine.你带药进来 瞄准谷氨酸。
156我看过一个,那就是Mbendazole。
157OK, how did I come to that realization?好吧,我是怎么意识到的?
158People knew that Mbendazole had some therapeutic benefit about cancer,人们知道Mbendazole 有一些治疗癌症的好处,
159but they don't believe until you show the mechanism.但他们不相信,直到你展示机制。
160That paper shows the mechanism.该文件显示了机制。
161It targets glucose and glutamine, this one targets glucose and glutamine.它针对葡萄糖和谷氨酸, 这个针对葡萄糖和谷氨酸。
162The two fuels driving the dysregulated growth of the tumor.两种燃料推动肿瘤生长不良。
163OK, so here's the here's the mitochondria.好吧,这是线粒体。
164So it's getting the glucose in the cytoplasm from the sugar因此,它得到了细胞质中的葡萄糖 从糖
165and making and fermenting that.制作和发酵。
166And then also the amino acid glutamine comes in.还有氨基酸谷氨酸
167You have to block the glycolysis and the glucose.必须阻断糖分解和糖分解.
168These two pathways, you have to restrict the availability of glucose这两种途径,你要限制葡萄糖的供应
169and glutamine together at the same time.和谷氨酸同时发生
170I speak only about things that I have tested in my lab我只谈我在实验室测试过的东西
171and published papers on like this.像这样发表论文
172So you have to realize that the cancer field doesn't understand所以,你必须意识到 癌症领域不明白
173that the cancer can't grow without glucose and glutamine没有葡萄糖和谷氨酸,癌症就无法生长
174and can't switch to fatty acids or ketone bodies.并且不能切换到脂肪酸或酮体.
175That's still not going to kill the cancer, though, is it?那还是不会杀死癌症,是吗?
176It's just going to.它只是去的。
177Yeah, we don't ever use the term cure because some of these tumors.是啊,我们从来没有使用术语 治愈因为一些这些肿瘤。
178Now, let me tell you, we have people like Pablo Kelly from Devon, England.现在,让我告诉你, 我们有像巴勃罗凯利这样的人 来自英国德文。
179He had the glioblastoma.他得了胶囊瘤
180He didn't take any radiation or chemo.他没有接受任何辐射或化疗.
181He just did metabolic therapy.他刚刚做了新陈代谢疗法。
182He lived for 10 years.他活了10年了。
183He was diagnosed with an inoperable glioblastoma.他被诊断为无动于衷的胶囊瘤。
184They wanted to irradiate and poison him with the drugs.他们想用毒品照射和毒死他
185He said, no, he was one of these naturalistic kind of guys.他说,不,他是这种自然主义的人之一。
186And he lived for 10 years and the tumor became operable.他活了10年,肿瘤开始可以手术。
187He had four debulking surgeries on an originally described inoperable cancer他做了4次手术 手术之前描述的癌症
188cut out four times, because once we put the metabolic therapy,剪掉四次,因为一旦我们把 代谢疗法,
189the circle, the demarcation of the tumor.圆圈 肿瘤的分界
190Well, there are neurosurgeons.有神经外科医生
191I think I can get this out.我想我可以把这个弄出来。
192But he never never got it.但他从来没有得到它。
193He lived with it for 10 years, had a couple of kids.他与它一起生活了10年,生了几个孩子.
194He died from a cerebral hemorrhage on the last debulking surgery.他死于脑溢血 在最后一次脱壳手术。
195He never died from the tumor.他从来没有死于肿瘤。
196But you're saying you're saying that the two work together in tandem.但你是说 两者合作
197You're saying that the chemotherapy works in.你是说化疗有效
198Now, that's where that's another thing.现在,这是另一回事。
199So what we do is very interesting.所以我们所做的非常有趣。
200So if you put the patient in nutritional ketosis,所以,如果你把病人 在营养性克特氏症,
201the ketogenic state of nutritional营养的致病状态
202ketosis facilitates the delivery of drugs to the tumor cell.酮化有利于向肿瘤细胞运送药物.
203It actually makes you can use lower doses of drugs这实际上让你可以使用低剂量的药物
204and you and you and you get bigger effect.和你,你和你有更大的效果。
205The therapeutic benefit increases with lower dosing.治疗福利随着剂量降低而增加。
206So you want to be in ketosis when you do these chemotherapy radiation.所以当你做这些化疗辐射时,你想在酮化中。
207And then you use much lower doses.然后用低得多的剂量。
208This is what we're doing in Istanbul Clinic.这是我们在伊斯坦布尔诊所做的
209We're taking pancreatic cancers.我们正在服用胰腺癌。
210These guys live in four and five years.这些人住4年5年。
211What are we doing?我们在做什么?
212And advanced breast cancer and all these terminal cancers.还有高级乳腺癌和所有这些末期癌症。
213We put them into some level of ketosis.我们把它们放进某种程度的酮化。
214然后,你进来 标准药物,Cisplatin,
215carboplatin, whatever you want to do.卡波白金,随便你
216But you cut the dosages down big time.但你把剂量削减了很多
217And then they have tremendous and you put the key.然后,他们有巨大的 你放钥匙。
218And this is what the title of the paper is, ketogenic diet这就是报纸的标题, ketogenic饮食
219as a metabolic vehicle作为代谢载体
220for enhancing therapeutic efficacy.提高疗效。
221The current body of research suggests that being in a state of ketosis目前的研究显示,科特氏症正在形成
222can act as a helper therapy, enhancing the cancer killing effects能够发挥辅助疗法的作用,增强癌症致死效果
223of chemotherapy while simultaneously protecting healthy cells.化疗的同时保护健康的细胞
224Yeah, yeah, right, right.对,对,对
225Progressive oncologists are currently using ketogenic diets进化肿瘤学家目前正在使用致癌饮食
226alongside standard chemo to maximize its efficacy.与标准化疗同时进行,以最大限度地提高其疗效.
227That's right.没错
228That's what we're doing in Istanbul.这就是我们在伊斯坦布尔做的。
229And also in Greece, we're doing we're doing those same things.在希腊,我们也在做同样的事情。
230So you can use this.这样你就可以用这个了
231When you enter a fasted or ketogenic state, your healthy cells当你进入禁食状态或基因状态时 你的细胞健康
232essentially go into bunker mode.基本上进入掩体模式。
233They slow their division, conserve energy and build up their defenses.他们减缓了分裂,节约了能源,建立了防御力量.
234Cancer cells, however, do not have this evolutionary off switch.然而,癌细胞并没有这个进化的关节.
235They continue trying to rapidly divide.他们继续试图迅速分裂。
236When the toxic chemotherapy hits, your shielded healthy cells当毒药化疗打中时 你的防护罩是健康的细胞
237survive it much better.活下来会好得多
238While the exposed, rapidly dividing cancer cells take the full hit.受辐射的癌细胞迅速分裂 将受到全面打击
239Yeah.对
240OK, interesting.好吧,有趣的是,你觉得呢?
241Yeah.对
242In other words, you make with the tools you have work better.换句话说,你用工具做的更好
243The problem in the field of cancer today is they're not using今天癌症领域的问题是 他们没有使用
244the tools in the correct way.以正确的方式使用工具。
245Now, let me give you another example.现在,让我举另一个例子。
246If you take immunotherapies, you hear about these things,如果你服用免疫外科, 你听说过这些东西,
247chimeric,抗原,T受体,PD-1,PD-L1等.
248They're called precision medicines, right?它们被称为精密药物,对不对?
249So look, they're designed to attack a molecule on the surface所以看,它们的设计是攻击表面的分子
250or stop that cell from being resistant.或阻止细胞的抵抗。
251If you were trying to attack and what they do,如果你试图攻击和他们做什么,
252oftentimes they come at after you failed chemo and radiation,你化疗和辐射失败后 他们经常会来
253they then come at you with an immunotherapy.然后用免疫疗法对付你
254The metabolic pressure shrinks down.代谢压力缩小.
255Your tumor makes it very indolent and non aggressive.你的肿瘤使得它非常无礼和无攻击性.
256And the rest of your body is healthy.而身体的其余部分是健康的.
257You're not going bald.你不会秃头的
258You're not bleeding gums.你没有流血口香糖。
259Your microbiome isn't blown to hell.你的微生物没有被吹到地狱。
260So and then you can come in with low dose chemo, immunotherapy,然后用低剂量化疗 免疫疗法
261because what's ever left in that remaining residual mass,因为留下的剩余物质
262they may all have something in common for having survived all this.他们可能都有共同之处 幸免于难
263Right.对
264So now you can come in with a precision medicine and possibly resolution.所以现在你可以用精密的药 和可能溶解。
265I thought this was fascinating.我觉得这很有趣
266It says chemotherapy creates massive oxidative stress,上面说化疗会产生巨大的氧化应力
267i.e.即说.
268damage inside the tumor to repair the damage and survive.肿瘤内部的损伤 修复损伤和生存。
269The cancer cell requires massive amounts of glucose.癌细胞需要大量葡萄糖.
270So if the patient is in ketosis, the tumor's glucose supply所以,如果患者在酮化,肿瘤的葡萄糖供应
271is essentially cut off.基本上被切断。
272It can't the cancer cell can't repair the DNA damage caused by your chemo,癌细胞不能修复你的化疗导致的DNA损伤,
273leading to faster tumor death.导致肿瘤死亡更快
274Yeah, interesting.对,很有趣
275Well, don't forget also listen to this.嗯,别忘了也听这个。
276And as another thing, people go in,另外,人们进去
277what protects the tumor cell from chemo and radiation如何保护肿瘤细胞免受化疗和辐射
278is the waste products of fermentation, the lactic acid and the succinic acid是发酵、乳酸和苏奇酸的废品
279that are dumped out of this raging beast,被弃绝的野兽,
280prevent these other therapies from working.防止其他疗法起作用。
281So if you want your therapy to work,如果你想让你的治疗起作用
282you've got to target those two fuels together at the same time.你要同时瞄准这两个燃料
283And when you do that, now this cell, the shield is off.当你这样做, 现在这个细胞,盾牌关闭。
284These things are super vulnerable to even low doses of chemo and radiation.这些东西甚至极易受低剂量化疗和辐射的伤害.
285And the immunotherapies look at if you have an immunotherapy,免疫者看看如果你有免疫疗法,
286you try to attack the beast when it's at its strongest.你试图攻击最强的野兽
287You're not going to win.你不会赢的
288And this is what happens.这就是发生的事情。
289You get only partial response.你只得到部分反应
290They in the field of cancer today, they think living an extra six他们今天在癌症领域, 他们认为生活额外的六
291months is a major breakthrough.几个月是一个重大突破。
292We're talking about living an extra five and six years.我们说的是多活五年六年
293This is what's really important.这才是真正重要的
294I just I was redoing some research to figure out if oncologists,我只是重新做了一些研究 找出肿瘤学家,
295so cancer doctors, are currently recommending the ketogenic diet.癌症医生们 正在推荐骨骼素食
296And it says the vast majority of mainstream oncologists它说绝大多数主流肿瘤学家
297do not recommend the ketogenic diet to their newly diagnosed patients.切勿推荐给新确诊的患者进行骨质减肥.
298In fact, if a patient brings it up, many doctors will actively advise against it.事实上,如果病人提出来,许多医生会积极劝阻.
299And the reasons for that, number one, is the fear of cackexia.而原因,第一, 是因为对卡克西娅的恐惧。
300Cackexia, cackexia, cancer.卡克西娅 卡克西娅 癌症
301Cackexia is a severe wasting syndrome where patients rapidly lose muscle and fat.Cackexia是一种严重的消瘦综合症,患者会迅速失去肌肉和脂肪.
302It is a massive problem and a leading cause of mortality in cancer patients这是一个大问题,也是癌症患者死亡的主要原因
303because the ketogenic diet suppresses appetite and often leads to weight loss.因为酮类的饮食抑制了食欲,并经常导致体重下降.
304Oncologists are terrified that a strict keto diet will accelerate肿瘤学家担心 严格的克托饮食会加速
305Cackexia)和弱化患者.
306Well, that's because they they have not heard what I just said那是因为他们没听到我说的话
307with respect to the biology and biochemistry.在生物学和生物化学方面。
308OK, cackexia, there's two ways you can lose in cancer patients.好吧 Cackexia 癌症患者有两种可能输掉
309Cackexia is the ability of the tumor cell to mobilize energy out of the muscles.Cackexia是肿瘤细胞从肌肉中调动能量的能力.
310It's taking the glutamine out of your muscles and feeding.它从肌肉中取出谷氨酸 并喂食。
311This is one of the two fuels that's driving the beast is glutamine.这是驱使野兽的两种燃料之一 是谷氨酸
312Where are they getting the glutamine from?他们从哪里得到的谷氨酸?
313They're getting the glutamine not only from the bloodstream,他们不仅从血液里得到谷氨酸
314but they dissolve your muscles as a as part of that part of that process.但他们会溶解你的肌肉 作为这个过程的一部分。
315So when you put a patient in nutritional ketosis,所以当你把病人 营养性酮化,
316the weight loss is therapeutic weight loss.体重减少就是治疗性体重减少。
317Cackexia是病理减重.
318The other way you can lose weight is you take a high dose of chemotherapy.另一种可以减肥的方法就是接受高剂量的化疗.
319I travel all the time.我经常旅行
320I made a rule in my life that I'll only travel with a cabin bag.我做了一个规则 我的生活,我将只旅行 与一个小包。
321The problem with this is not much space.问题不在于空间。
322And here's the solution.而此解义.
323It is called an extra one percent travel pack.这被称为额外的1%旅行包。
324And I teamed up with extra to make this.我加了额外的钱来做这个
325Typically, I can only bring some of my black shirts,通常我只能带一些黑色衬衫,
326and it's a trade off of which black shirt should I bring.换来一件黑色衬衫
327How many of these do you think I can get in here?你以为我能进来多少次?
328So let's try one, two, three, four, five, six, seven, eight, nine, ten,故试一二三四五六七八九十.
329eleven, twelve, thirteen, fourteen.十一、十二、十三、十四,请讲
330Let's try fifteen, sixteen, seventeen, eighteen, nineteen, twenty, twenty one,让我们尝试十五,十六,十七,十八,十九,二十,二十一,
331twenty two, twenty three, twenty four.22,23,24号
332OK, so that's twenty four black t-shirts.好吧,这是二十四件黑色T恤。
333Here's where the magic comes in.魔力从这里来.
334Zip it up, make sure it's nice and sealed and then use this little contraption.把它塞上,确保它很好,密封 然后使用这个小装置。
335Stick on there.坚持住
336I can now take more than twenty black shirts with me,我现在可以带着二十多件黑衬衫
337which will last me three weeks.这将持续我三周。
338So if you travel frequently and you want to get one of these,所以如果你经常旅行 想得到一个这样的,
339you can save more space and be away for longer.你可以节省更多的空间 离开更长的时间。
340Go to extra dot com and use code DOAC for 10 percent off our collection.去额外的点com 并使用代码DOAC 从我们的收藏10%。
341And I think some of the background context here is that mainstream ecology我认为这里的一些背景背景 是主流生态学
342operates on the sort of somatic mutation therapy, which is the belief that cancer以某种生理突变疗法为主 认为是癌症
343is fundamentally a genetic disease driven by DNA mutations.本质上是一种遗传性疾病 由DNA突变驱动。
344And because their training focuses on genetics, their treatments are designed因为他们的训练集中在遗传学上 他们的治疗设计
345to target DNA and cell division by chemo radiation targeted genetic therapies以化疗辐射为靶向DNA和细胞分裂
346rather than manipulating cell cellular metabolism.而不是操纵细胞细胞代谢
347And lastly, as mentioned, I think we talked about this earlier.最后,如前所述,我想我们之前谈过了。
348Mainstream medicine requires massive, multi-centred, double blind主流医学需要大规模,多中心,双盲
349phase three clinical trials before a protocol becomes the standard of care.在协议成为护理标准之前进行第三阶段临床试验。
350So dietary interventions rarely get the level of funding.因此,饮食干预很少获得资金。
351So oncologists lack the institutional green light to prescribe them to patients.因此肿瘤学家缺乏 机构绿灯 给病人开药。
352And they tend to say to them, eat what you can.他们往往对他们说,吃你能吃的东西。
353I don't blame them.我不怪他们
354They're good.他们是很好的。
355Many of them are good people.许多人都是好人
356The problem is the system doesn't train them to understand the biology问题是系统不能训练他们理解生物学
357and biochemistry of the disease they're treating.和生物化学 他们正在治疗的疾病。
358Some of them become very resistant.其中一些人变得非常有抵抗力.
359They say, get angry because if I why didn't I why wasn't I told this?他们说,生气是因为如果我不说 为什么没人告诉我?
360Well, first of all, they're not reading these papers.首先,他们不读这些文件。
361You asked them about it.你问他们这件事。
362I never read it.我从未读过
363Well, how are you going to know anything if you don't read the literature?好吧,如果你不读文献,你怎么会知道?
364Listen to this.听这个。
365The National Cancer Institute, the NCI, on their website, on their website,国家癌症研究所 国家癌症研究所 在其网站上 在其网站上
366says cancer is a genetic disease caused by what you just said.说癌症是遗传性疾病 由你刚才说的话。
367OK, they well, I said, why don't they put the articles in there好吧,他们很好,我说, 他们为什么不把文章在那里
368showing all the tumors?显示所有的肿瘤?
369They can't find any mutations.他们找不到任何突变
370The somatic mutation theory says that cancer is caused by random genetic mutations.生理突变理论说癌症是由随机遗传突变引起的.
371So now new sequencing of normal people like you and me现在像你和我这样的普通人有了新的顺序
372are finding mutations in all these driver genes and cells in our body我们体内所有这些驱动基因和细胞的突变
373that aren't in dysregulated cell growth.这在细胞生长过程中并不存在
374So we're calling them wild type cancers.所以我们叫它们野性癌症。
375We mean a wild type cancer.我们是指一种野性癌症
376You lost me.你失去了我。 。 。
377OK.摆
378The nucleus of a tumor cell, a raging tumor cell,一个肿瘤细胞的核, 一个暴动的肿瘤细胞,
379what's causing him that cell to grow?什么让他的细胞生长?
380Is it the mitochondria in the cytoplasm or is it the mutations in the nucleus?是细胞质中的线粒体还是核中的突变?
381OK, so according to the somatic mutation theory,好吧,所以根据 生理突变理论,
382it's the mutations in the nucleus that are causing the dysregulated cell growth.它是核糖体的突变 导致细胞生长障碍
383You take that nucleus and put it into into an enucleated normal cell.你拿那颗核 把它放进一个细胞内
384Yeah, and there's no cancer.是啊,没有癌症。
385No cancer.没有癌症。
386There's no dysregulation.戒律无滞.
387There must be something else.一定有别的东西
388Then you take the nucleus of the normal cell然后用正常细胞的核
389and put it into the cytoplasm of a tumor cell.把它放进肿瘤细胞的细胞质中
390And you get dysregulated cell growth.细胞发育不良
391So it must be something other than the nucleus.所以,它一定是别的东西 核。
392Yes, the mitochondria.是的,线粒体。
393Interestingly, it says.有趣的是,它说。
394So mitochondria controlling our destiny.线粒体控制着我们的命运
395And the field of cancer has yet to understand it, accept it而癌症领域 还没有理解它,接受它
396and then say, well, we can't do any of this until we double line cross.然后说,嗯,我们不能做任何这一切 直到我们双线交叉。
397So that's just what do you mean?这就是你的意思?
398The science is telling us this.科学告诉我们这一点。
399That's your way of protecting a broken system.这就是你保护破系统的方法
400Are you pissed off about this?你生气吗?
401Because you do seem pissed off about this.因为你似乎很生气
402Well, who wouldn't be?谁不会呢?
403Steven, there's one thousand seven hundred people a day史蒂芬,每天有一千七百个人
404in this country dying from cancer.这个国家死于癌症。
405I don't know the English.我不知道英语。
406Listen, that comes out to 70 an hour and it gets worse every single year.听着,这出 每小时70, 它越来越糟糕的每一年。
407And the last time I was on the show, you guys use some old data.上次我上节目时 你们用了一些老数据
408Look it up today.今查其迹.
409It's twenty twenty six.时年二十六.
410American Cancer Society says this year in twenty twenty six,美国癌症协会说,今年26,
411we will have six hundred and twenty six thousand souls我们将有62万6千个灵魂
412leave the planet from cancer.让地球远离癌症
413OK, this twenty twenty six.好吧,这26。
414And every year it gets worse.而逐年变坏.
415So when you hear all the breakthroughs, we have we have television ads所以,当你听到所有的突破, 我们有电视广告
416in Boston for the cancer.在波士顿的癌症。
417Breakthrough after breakthrough after breakthrough.突破后突破.
418All these different they come on.所有这些不同 他们来了。
419And all we do is get more dead cancer patients.我们所做的就是让更多的癌症患者死亡。
420Raise money for cancer.为癌症募集资金.
421Where's the where's the accountability for all the money you're raising?你所筹钱的责任在哪里?
422When are the work?什么时候工作?
423When is the people going to wake up?人民什么时候醒?
424You don't make someone healthy by irradiating and poisoning them.你不能通过辐照和毒害别人而使别人健康
425You've got to understand the biology and the biochemistry of the disease.你必须了解疾病的生物学和生物化学.
426I have the concepts and the proofs,我有概念和证据,
427but the physician who works with the patient on a clinic basis,但与病人同住的医生,
428they're the ones that must apply this to the clinic.他们必须把这个应用到诊所。
429So there's two different things here is the hard science.这里有两个不同的是硬科学。
430That's that's the bedrock for this.这就是这个的基础。
431And then there's the clinical person who has to practice that practice然后是临床医生必须练习
432does that together.一起来
433You get great success or better.你得到了巨大的成功或更好的。
434I say success better than anything that's out there today.我说成功胜过今天一切
435The American Cancer Society recently released its latest projections for 25美国癌症协会最近公布了对25美元的最新预测。
436and 26, and the data paints a fascinating dual sided picture.和26, 数据描绘了一个迷人的双面图片。
437More people are getting diagnosed with cancer.更多的人被诊断患有癌症。
438New cases, the ACS projects over two point one one million新案件,加勒比国家联盟项目超过20万
439new cancer diagnoses in twenty twenty six.新癌症诊断26。
440This translates roughly to five thousand eight这相当于五千八
441hundred new cases every single day.每天有一百个新病例
442Approximately six hundred and twenty six thousand Americans are expected估计有626万美国人
443to die from cancer in twenty twenty six.26岁时死于癌症
444Right.对
445About one thousand seven hundred deaths per day.每天约一千七百人死亡.
446Lung cancer remains the leading cause of cancer death肺癌仍是癌症死亡的主要原因
447projected to cause more fatalities than colorectal colorectal预计造成死亡的人数比直肠切除人数多
448and pan pancreatic cancers combined.还有胰腺癌
449I also just wanted to pick a whole point we were talking about earlier,我还想挑一个我们之前谈到的要点
450which is about the metabolic approach to cancers.这涉及到癌症的代谢方法。
451It says here, and this is going to the point about, you know,上面写着,现在要说的是,你知道,
452people telling you to just eat whatever you want while you're,别人叫你吃你想要的东西
453you know, managing cancer,你知道,管理癌症,
454because the primary goal of the hospital dietitian is to prevent weight loss因为医院饮食学家的首要目标是防止体重下降
455during brutal chemotherapy regimes.在残酷的化疗制度下
456Patients are frequently told to eat whatever they can病人经常被叫吃他们能吃的
457and eat whatever they can keep down.吃他们能吃的。
458It is incredibly common for cancer patients to be handed meal给癌症患者送餐是很常见的
459replacement shakes, which are often packed with corn syrups and refined sugars,更换的摇摆,这些摇摆往往用玉米糖浆和精制糖包装,
460ice cream and high carbohydrate comfort foods冰淇淋和高碳水化合物舒适食品
461just to keep their calorific intake up from a metabolic perspective.从新陈代谢角度 保持摄入热量
462This is a tragedy.这是一个悲剧。
463While it keeps weight on the patient, it simultaneously floods虽然它能保持病人的体重,但它同时淹没
464the bloodstream with glucose and insulin directly feeding the tumour.用葡萄糖和胰岛素直接喂养肿瘤的血液。
465And while keto is not the standard of care,虽然keto不是护理的标准,
466the landscape is beginning to slowly shift.地貌开始慢慢改变
467There is a growing minority of integrative oncologists越来越多的综合肿瘤学家
468and specialised metabolic clinicians worldwide that actively prescribe以及世界各地积极开处方的专业新陈代谢临床医生
469therapeutic ketosis alongside conventional treatments.治疗性酮化和常规治疗。
470Those doctors use the keto diet and fasting protocols to protect healthy cells那些医生用克托饮食和禁食协议来保护健康的细胞
471and sanitise tumours before administering lower, more targeted doses of chemo.在进行较低、更有针对性的化疗之前,先消毒肿瘤。
472That's what we develop.这就是我们的发展。
473That's our plan.这是我们的计划。
474That's what we're doing.这就是我们在做什么。
475OK.摆
476We do that because we understand the biology and biochemistry.我们这样做是因为我们了解生物学和生物化学。
477And that's why we develop.这就是为什么我们发展。
478We're developing the new society called MOAR, the MOAR Alliance,我们正在发展新社会 叫做MOAR,MOAR联盟,
479Metabolic Oncology, Research and Education.冶金肿瘤学,研究与教育.
480This is bringing together what you just mentioned there这把你们刚才提到的事情汇集在一起
481in a logical approach to manage cancer.以逻辑方法管理癌症。
482This is a logical approach based on the hard science of decades of research这是一个逻辑方法 基于硬科学 几十年的研究
483initiated originally by Otto Werberg and then continued by our group最初由Otto Werberg发起,然后由我们集团继续
484at Boston College.在波士顿学院
485The American Cancer Society says that breast cancer is increasing.美国癌症学会称乳腺癌在增加.
486Prostate cancer is increasing.前列腺癌在增加。
487Pancreatic cancer, melanoma, HPV associated,胰腺癌 黑色素瘤 与HPV有关
488oral cancers are steadily increasing in the incidence of severe cancers.口服癌症发病率稳步上升。
489Yeah, there has been no major advance是啊,没有重大进展
490在100年后管理glioblastoma。
491What's glioblastoma?什么是胶囊瘤?
492That's the deadly brain cancer.这就是致命的脑癌。
493OK, that killed Teddy Kennedy from Massachusetts, Senator Kennedy,那杀死了来自马萨诸塞州的泰迪肯尼迪 肯尼迪参议员
494John McCain, President Biden's son, Bo Biden.约翰·麦凯恩,拜登总统的儿子,博·拜登.
495It's killed a lot of various people and it's considered a death sentence.它杀死了许多不同的人,被认为是死刑.
496No, no, no, no.释曰.
497We're keeping these guys alive.我们要让这些人活着
498OK, we're not saying we cure the cancer,好吧,我们不是说 我们治疗癌症,
499but we can certainly keep them alive a lot longer.但我们可以让他们活得更久
500Pancreatic cancer, always considered so bad.胰腺癌,总是认为如此糟糕。
501We're getting very excellent results in managing pancreatic cancer我们管理胰腺癌的结果非常好
502using metabolic therapies.使用代谢疗法。
503We know what to do and we know how to do it.我们知道该怎么做,知道怎么做。
504I have clinicians that work with me, dieticians that know how to manage cancer我有临床医生和我合作, 饮食医生知道如何管理癌症
505effectively.有效地。
506We can do it right now, today.我们可以现在就做,今天。
507If someone were to say, Siefried, get your get your group together.如果有人说,Siefried, 让你的团队在一起。
508Let me see what you can do.让我看看你能做什么。
509I will put up our metabolic therapy against any trial我会用新陈代谢疗法来对抗任何试验
510from any of these pharmaceutical companies.任何一家制药公司
511We can keep these people alive a hell of a lot longer to participate我们可以让这些人活得更久些
512in our society.在我们的社会中。
513We're not doing that.我们不这样做。
514If you were made president today.如果你今天成为总统的话
515Of the United States?美国?
516Of the United States.美国
517Don't go there.别去那里。
518I'm going to go there.我要去那边。
519Those guys are not, let's put it this way,那些人不是 我们这么说吧
520they're not scientifically literate.他们没有科学知识
521I would have to be.我会是。
522Yeah, right.没错
523Professor Thomas Siefried, you're now President of the United States托马斯·西弗里德教授 你现在是美国总统了
524and your primary objective is to bring down this而你们的首要目标 就是把这个
5251,700 Americans that are going to get cancer a day.每天有1700名美国人得癌症
526Is it get cancer or die from cancer?是癌症还是死于癌症?
527No, they die from cancer.不,他们死于癌症。
5281,700 a day dying from cancer in the United States, 70 an hour.每天在美国死于癌症的有1700人,每小时70人.
529Think about it.考虑一下
530You can put in place policies to stop this happening你可以制定政策阻止这种情况发生
531and to also help people manage it better.还帮助人们更好地管理它。
532What is it you do?你这是干什么?
533First of all, we wouldn't throw out everything.首先,我们不会把一切都扔掉
534Just like I said, we have a strategy now to manage cancer effectively.正如我所说,我们现在有一个战略来有效管理癌症。
535OK, so you're not going to prevent it.好吧,所以你不会阻止它。
536We're not going to get rid of the drugs that are making billions我们不会去除 毒品正在产生亿
537and billions of dollars.和数十亿美元。
538We're just going to use them at lower doses in a different way.我们只是用低剂量 以不同的方式。
539But you also want to prevent it in the first place.但你一开始也想阻止它
540Well, preventing it, that comes back to our chart.好吧,防止它, 这回到我们的图表。
541I'm going to write down the manifesto.写下宣言.
542So what is what do we do to prevent these 71 people an hour dying of cancer?那么我们该怎么办来防止这71个人 每小时死于癌症?
543Well, that has to come from government policies.这必须来自政府的政策。
544OK, you just got promotion.好,你刚升职了
545You're now the king of the United States.你现在是美国国王了
546So you don't even need to ask anybody.所以,你甚至不需要问任何人。
547What do you do to prevent the 71 people a day dying of cancer?你做什么来防止71人每天死于癌症?
548It's going to be education.将作教育.
549Education number one.教育第一.
550OK, you have to let people know that those.好吧,你必须让人们知道这些。
551And now let me tell you another thing that's really important.现在让我告诉你另一个很重要的事情。
552It should not be any government or government official它不应该是任何政府或政府官员
553telling anyone what they should or should not eat.告诉别人他们该不该吃什么
554OK, the power of this chart is personal.好吧,这个图表的力量是个人的。
555You're emboldening the patient.你让病人胆大妄为
556They have to know.他们必须知道。
557We're not going to tell somebody, oh, if you continue to eat bad food,我们不会告诉别人 如果你继续吃坏食物
558you're going to have you're at high risk.你会有你 在高风险。
559And that person, I don't care.还有那个人 我不在乎
560I'll smoke cigarettes.我要抽烟
561And I'm well, the government is not going to come into this guy's house我很好,政府不会进这家伙的家的
562and take away the bad food.并夺去恶食.
563No, no, no, no, that should never happen.不,不,不,不,那不应该发生。
564Those foods are there because they give us pleasure.那些食物在那里 是因为它们给我们带来乐趣
565But they should be the knowledgeable person would be to say,但他们应该是有知识的人 会说,
566I like to have it every now and then, but I can't live in that environment.但我不能生活在那种环境中。
567And the other thing we do terribly in this country, the poor people还有一件事,我们做可怕的 在这个国家,穷人
568in these food deserts where you only get crap food在荒漠的食物中,你只得到垃圾的食物
569and as there's a tragedy in itself,和有悲剧本身,
570they to go to whole foods where they have the expensive rib eyes他们去食物 在那里他们有昂贵的肋眼
571and all this stuff, that's much more expensive.而这些东西, 那要贵得多。
572A lot of people can't afford the kinds of foods很多人买不起食物
573that will put them in these better healthy zones.让他们进入健康地带
574So we're going to make food, healthy food, more cost所以,我们要做食物,健康的食物, 更多的成本
575cost effective, cheaper.成本效益高,价格低廉。
576Those are easy words to say, but in practicality, it's not.这些话很容易说,但实际上并非如此。
577What kinds of food should people be eating?人们应该吃什么样的食物?
578Well, I think they should just try to avoid the highly processed carbs.我想他们应该尽量避免 高加工的碳水化合物。
579OK, you don't listen to this.好吧,你不听这个。
580You and exercise.你和锻炼。
581There's a lot of things we can do我们有很多事情可以做
582that would mitigate the inflammatory conditions put on this chart.将减轻本图表中包含的煽动性条件。
583The goal here is we know what keeps us healthy.这里的目标是,我们知道什么使我们健康。
584It's the efficiency of that organelle.这是那个管风琴的效率。
585We want to do everything possible to keep that organelle healthy.我们想尽一切可能 保持这个器官的健康。
586We will reduce dementia.我们会减少痴呆症。
587We will reduce diabetes.我们将减少糖尿病。
588We will reduce obesity.我们将减少肥胖症。
589And they say, well, GLP, why don't I don't want to do it?他们说,嗯,GLP,为什么不我不想这样做呢?
590And human beings are the kind that I want a quick fix for everything.而人类是我想要的 快速解决一切。
591Right.对
592Azempec.阿赞培克.
593来点Azempec怎么样?
594Is this what is this?这是什么?
595GLP吗?
596对,GLP一号
597OK, we don't, you know, first of all, we haven't done any research yet to know好吧,我们没有,你知道, 首先,我们还没有做任何研究 还没有知道
598where a GLP would put you on the chart.GLP会把你放在图表上
599We do know one thing.我们确实知道一件事。
600It lowers blood sugar.它会降低血糖。
601How high of a level would it bring to ketone?它能给酮带来多高的水平?
602Because it's the ketones that keep the organelle healthy.因为是酮使风琴保持健康.
603So I'm lowering blood sugar, but am I raising the ketones所以,我降低血糖, 但我是提高酮
604that enhance the bio energetic efficiency of the organelle?提高风琴的生物能量效率?
605I don't know what number hasn't been done yet.我不知道什么号码还没有完成。
606I don't I haven't seen any papers coming out.我没有看到任何文件出来。
607OK, so we'll keep the azempec off the table.好吧,所以我们会保持 ACEmpec的桌子。
608But you're saying exercise number three.但你说的是三号运动
609So I've got I've got education.故有修习.
610Kill the food deserts so people can get healthy food.消灭食物荒漠,让人们得到健康的食物.
611Yeah.对
612Stay away from the ultra-process stuff.远离超程序的东西。
613Number three, exercise.第三,锻炼。
614We're going to give everybody free gym memberships and whatever else they need.我们要给每个人免费的健身会员 和他们需要的任何东西。
615Reduce stress, emotional stress.减轻压力 情绪压力
616You got to you got to do that.你必须这样做。
617There's a lot of ways music therapy is a lot of different ways.音乐疗法有很多不同的方式.
618You got meditation, friends, happiness, all of those reduce stress.你有冥想,朋友,幸福,所有这些减轻压力。
619So I had I had a guy from Korea.所以我有个韩国人
620I think it was Japan or Korea.我想是日本还是韩国
621We had a big meeting one time and he didn't tell me what to do.有一次我们开了个大会 他没告诉我该怎么做
622He says, you want to get cancer if your job and if your goal in life is to get cancer.他说,你想得癌症 如果你的工作 如果你的生活目标是得癌症。
623You got to eat crap food all the time.你总得吃烂东西
624You have to have terrible sleep.你得睡个好觉
625Make sure you never unask the couch.确保你永远不要揭开沙发
626Sit in front of the TV all day.整天坐在电视前
627Look at doom scrolling.看看末日的卷轴
628Do all that kind of stuff.做所有这些事情。
629Make sure you never exercise and make sure you don't have any friends or be happy.确保永远不要锻炼,确保自己没有朋友或快乐.
630You're on the fast track for not only cancer, but all these other chronic diseases.你不仅因为癌症,而且因为其他的慢性病,正在快速前进。
631So so that's the what I just said, you need to not do that.所以这就是我刚才说的,你不必这么做。
632You're doing a great job.你干得不错
633That's not many people are going to be measuring their GKI every day.每天衡量GKI的人不多了
634But there are people who love to measure that kind of stuff.但有些人喜欢测量这种东西。
635Now, I would say I have another thing.现在,我要说我还有一件事
636So they put these things on your arm, these continuous sugar monitors.所以他们把这些东西放在你的手臂上 这些连续的糖监测器
637They're making continuous glucose ketone monitors.他们正在做连续的葡萄糖酮监测器.
638So apps are coming out now.应用软件现在出来了
639Believe me, there's apps.相信我,有应用软件
640I have my Lucas Liu and some others are making these apps in my lab.我的Lucas Liu和其他一些人在实验室里做这些应用软件
641And you can take your cell phone and and photograph a particular food item.你可以拿起你的手机 拍下特定的食品
642And and the food item immediately you put the places你马上把食物放好
643where the food item on the chart.在图表上的食品。
644So you'll know eating that will give you what zone you'll be in if you eat it.所以,你会知道 吃,会给你 是什么区域,如果你吃了它。
645So it's really interesting.所以这真的很有趣。
646And these things are coming.这些东西就要来了。
647We're using AI to so but it's purely patient empowerment.我们用人工智能来达到这个目的,但这纯粹是增强耐心的能力.
648OK, the patient themselves, the person themselves make the choices.好吧,病人自己, 个人自己做选择。
649No government president or king or whatever you want to say没有政府主席或国王 或是你想说什么
650should ever tell people what and how they should eat.应该告诉人们他们应该吃什么和怎么吃
651The patients should be familiar with this and have the knowledge to know病人应该熟悉这个 并且知道
652I'm going to test what I think.我要测试我的想法
653So people say to me all the time, well, just tell us what you can eat.人们总是对我说, 告诉我们你能吃什么。
654That's all they say to me.他们只跟我说这些
655OK, eat whatever you want.好,随便吃什么
656You figure out where on the chart you're going to be and then you'll know.你想想图上你会是哪里 然后你就会知道
657So people say, well, I can't eat ketogenic diet.所以人们会说,嗯,我不能吃 ketogenic饮食。
658Well, our group in in Greece now you tell me好吧,我们在希腊的团体 现在你告诉我
659they got the brain cancer tremendous success in keeping brain他们的脑癌在保持大脑方面非常成功
660glioblastoma guys alive.胶囊瘤的人还活着。
661What was the diet?饮食怎么样?
662It was a calorie restricted Mediterranean diet.是卡路里限制地中海饮食的
663Salmon, sardines, olive oil, avocado and exercise.沙门 沙丁鱼 橄榄油 鳄梨和锻炼
664Is that like, oh, man, that's the worst diet.这是像,哦,男人, 这是最糟糕的饮食。
665What about the carnivore?食肉馆呢?
666What about the rib eye with a little sauce brunettes on top of it?肋眼上面有小酱油褐色呢?
667This keeps your blood sugar low and elevates your ketone.这让你的血糖低 提高你的酮。
668If you want to do it with plants, everything, you got fish, plants,如果你想用植物,一切, 你有鱼,植物,
669you get the vegans and all these kind of people.你得到素食者 和所有这些类型的人。
670This is a bio energetic road map to health.这是一个具有生物活力的健康路线图。
671Let me just give some specific.让我说几句话
672So this is amazing.所以这是惊人的。
673What about high fructose corn syrups and refined?高果糖玉米糖浆和精制呢?
674Oh, man, that's the worst kind of crap.哦,伙计,这是最糟糕的废话。
675You don't take that.你不拿那个。
676What about what about industrial seed oils?工业种子油怎么办?
677Well, you know, people talk about seed oils and canola and soy.嗯,你知道,人们谈论 种子油和油和豆子。
678Yeah, I don't know, but every it was another thing, too.是的,我不知道,但每一样都是另一回事。
679You and I are different.你和我不一样
680We have an individual metabolism, age,我们有个人的新陈代谢,年龄,
681race, sex, all the religion, all kinds of stuff种族,性,所有宗教,各种东西
682determine what and how you live.决定你的生活和生活
683And I can't be sure what you eat, what I eat or what you exercise,我不确定你吃什么 我吃什么 你锻炼什么
684where it's going to put to put us on the chart.它会把我们放在图表上
685Synthetic pesticides.合成农药.
686I was really here that increases the chance of lefoma by staggering 41 percent.我在这里真正增加了 淋巴瘤的机会 惊人的41%。
687They all damaged the oxidative phosphorylation,它们都损坏了氧化磷酸盐,
688putting the cell at risk for compensatory fermentation,使细胞面临补偿性发酵的风险,
689dysregulated cell growth.抑制细胞生长.
690Wow.珃
691The problem, the problem, the field doesn't understand问题,问题,球场不明白
692what I'm saying with respect to the origin of cancer,我想说的是癌症的起源
693how it happens mechanistically,如何在机械上发生,
694how this organelle controls the life of the cell.如何控制细胞的生命。
695They don't know enough about the biology and biochemistry of the mitochondria.他们对线粒体的生物学和生物化学了解不足.
696You want to get guys on here like Nick Lane from England.你想像英国的尼克·莱恩一样 带人来这里
697I mean, these guys like Doug Wallace and some of these guys,我的意思是,这些家伙 像道格华莱士和其中一些人,
698they're mitochondrial biologists.他们是线粒体生物学家。
699They they understand this kind of stuff.他们知道这种东西。
700I want to give people actionable things that they can think about.我想给人们一些他们能想到的 行动的东西
701So that's why I was asking you this question about you becoming king.所以我才问你 你成为国王的问题
702Fasting protocols.斋戒协议.
703Well, OK.好吧,没关系。
704Intimidate fasting.摄受斋戒.
705Let me let me talk about that just briefly.让我简单谈谈这个问题。
706Do you ever try it?你试过吗?
707Yeah.对
708What do you think?你觉得呢?
709You liked it?你喜欢吗?
710It depends how long you're talking about.这取决于你在说多久。
711OK, let's go a week.好吧,让我们去一个星期。
712Oh, no, I'm not fasted for a week before.哦,不,我一个星期前没有禁食。
713OK. You know, it is the call the wall.摆 你知道,这是叫墙。
714This guy, he just sent me his book.这家伙刚把书寄给我
715It's coming out.师出曰.
716A very nice guy, Virol Simac.一个很好的人,维罗尔・西马克。
717He say people share things with me.他说人们和我分享一切
718The wall is after about three days of not eating, just drinking water.墙壁经过三天左右的不吃,只是喝水.
719You hit this wall and it's like, oh, man, I'm just I can't deal with it anymore.你撞到这面墙,我受不了了
720It's just a terrible feeling in my body.我身体里只有可怕的感觉
721I can't sleep at night.夜不眠卧.
722I got the jimmy legs.我得到了Jimmy的双腿。
723I got all kinds of problems.我有各种各样的问题。
724Screw it.他妈的。
725I'm not doing this.我不会这么做的
726He found out if you sip just tiny amounts of a grape juice,他发现如果你喝了一点葡萄汁
727you can get get through the wall.你可以通过墙壁。
728What we do for the cancer patients in the way we design our clinical procedures,我们如何为癌症患者 设计我们的临床程序,
729which my clinical friends, we do a zero carb diet for about a week我的临床朋友们, 我们做了一个零碳食谱 大约一个星期
730while the body is readjusting, getting, getting, bringing them out of the red zone,身体在重新调整, 得到,得到,带出红色区域,
731getting into the yellow zone.进入黄区。
732You can't believe the power of glucose is an addictive drug on the brain.无法相信葡萄糖的力量是大脑上瘾的药物.
733It's unbelievable.难以置信
734It's like cocaine.这就像可卡因。
735It's it's and you know that when you start, you start shaking and you go.这是它,你知道 当你开始,你开始颤抖,你走。
736So but if you don't eat carbs and just eat meat or whatever, to keep you in a low GKI,所以如果你不吃碳水化合物 吃肉什么的 让你处于低谷状态
737then when you jump off to the water only fasting, it's much less traumatic to the brain.当你跳到水里只禁食时, 对大脑的创伤就小得多了。
738You've gone through the wall of the gate, so to speak.你穿过了城门的墙 所以说
739So once you know how to get through the gate, you make this whole process所以,一旦你知道如何通过大门, 你做了整个过程
740a lot a lot easier.更简单多了
741And that helps people enormously, especially those people这对人们,尤其是那些
742that want to get rid of their chronic disease.想要摆脱他们的慢性病。
743OK.摆
744Because or some, you know, we have a lot of people out there因为或者有些人,你知道, 我们有很多人在那里
745that just like to do all this stuff.喜欢做这些事情。
746You know, you've got these these people that go overboard on everything.你知道,你已经得到了这些人 过关的一切。
747But, you know, right now we have an obesity, chronic但是,你知道,现在 我们有一个肥胖,慢性
748epidemic, cancer epidemic.传染病、癌症传染病。
749All of these epidemics are the result of an abuse of that organelle所有这些流行病都是滥用器官的结果
750in one way or another.以某种方式。
751And we have a plan to mitigate that abuse.我们有一个计划来减少这种虐待。
752And at least people haven't at least they're empowered to do it至少人们还没有被赋予权力
753with the help of knowledgeable physicians.在有知识的医生的帮助下
754I want to just keep on this point of actionable feedback.我只想保持这个可采取行动的反馈点。
755So Dr. Volta Longo's doctor, his extensive research, clinical trials所以沃尔塔·隆戈博士的医生 他的广泛研究 临床试验
756prove that fasting, mimicking diets drastically lower IGF one,证明禁食,模仿饮食 大幅降低IGF一,
757which triggers cellular autophagy and actually make standard cancer therapies引发细胞自失能 并实际制造标准癌症疗法
758up to three times more effective by removing the metabolic shield of cancer cells.通过去除癌细胞的代谢屏蔽,其效果最高可达三倍.
759Yeah, which is the glucose, the waste products of glucose,是的,这是葡萄糖, 葡萄糖的废品,
760which is the lactic acid and the succinic acid.是乳酸和苏奇酸
761That all goes down.这一切都过去了。
762Would you recommend again, if you're king, would you recommend that?如果你是国王 你会再次推荐吗?
763I would never recommend and I have to just give them the knowledge.我永远不会推荐,我只得给他们知识。
764Then the person has to make the decision themselves.那人必须自己做决定
765Do you think it could be beneficial?你觉得这样有用吗?
766Of course.当然
767If you were king to have everybody wear a CGM,如果你是国王 让每个人都穿CGM,
768one of those continuous glucose monitors, at least once.一个连续的葡萄糖监视器,至少一次。
769No, never.没有,从来没有。
770No, I think if you have cancer and you really want to stay in this green zone to know.不,我想如果你得了癌症 你真的想留在这个绿区去了解
771Right.对
772Listen, I was down in Mexico not long ago.听着 我不久前在墨西哥
773I was talking to one of the head physicians down there.我和下面的一位医生谈过
774He wore one of these things, right?他穿这种衣服,对吧?
775He said, every time I wanted to go out and have a party, have a good time,他说 每次我想出去开派对 玩得开心
776this damn thing would be beeping.这该死的东西会鸣叫。
777So what do you rip it off and threw it in the trash?你把它撕下来扔进垃圾桶里?
778So you don't want somebody barking in your ear when you're having a good time.所以你不希望有人在你耳边吠 当你有一个好时机。
779That's why what you're doing right now with this, you're choosing to prick your finger.这就是为什么你现在这样做, 你选择刺你的手指。
780You're the one making that decision.是你自己决定的
781There's not something on your arm saying, Steven, don't do that.史蒂芬,你手臂上没有东西说,别这样
782Don't do that.别这样
783But you know what?但你知道吗?
784It was useful to wear it once or twice, because it even I could.穿一两次很有用,因为我也能穿
785I suddenly realized that things I put in my mouth had an impact on my blood sugar,我突然意识到我嘴里放的东西 对我的血糖有影响
786on my blood, which also I realized that had an impact in 10 minutes.在我的血液中,我也意识到 这在十分钟内产生了影响。
787And then and then also when my blood sugar came back down and crashed,然后,当我的血糖 回来并坠毁,
788I thought, oh, gosh, I feel I could suddenly pair my behavior to my feelings.我想,哦,天哪,我觉得我可以 突然我的行为与我的感受。
789Yes.对
790Well, that now I know I've seen that.嗯,现在我知道我已经看到了。
791And not only that, Andrew Scarborough from England, who's been doing this for不仅如此,来自英国的安德鲁·斯卡伯勒 一直以来都是为了
792for stage three glioma, he's like 15 years out.他大概15年没睡了
793He's done this so many times with the finger prick and all this.他用手指刺和这一切做了很多次
794He knows that already when his body is in these zones from the feeling that you他已经知道 当他的身体在这些区域 从感觉你
795just described.刚才说的
796But for the people at the beginning and who are given a terminal但对于人们来说,在开始的时候, 谁是被给予终点站的
797diagnosis, they want to get into these green zones and they want to use the他们想进入这些绿色区域 他们想使用
798things that are going to keep them alive on the planet for a longer period of让他们在地球上活得更久
799time with a higher quality of life.拥有更高的生活质量
800That is important.这很重要。
801That thing on your arm can help you stay in that zone until you have this thing手臂上的东西可以帮助你留在那个区域 直到你得到这个东西
802managed, at which time you can choose when to do that.管理, 您可以选择何时这样做 。
803So this flexibility in this whole process, it's not one like, for example,所以,在这个整个过程中的这种灵活性, 它不是一个像,例如,
804we have the standard of care, which is written in granite for crying out loud.我们有护理的标准, 写在花岗岩上 用于大喊大叫。
805They get all they if you do anything different from the standard of care, you他们得到所有,如果你做 任何不同的标准护理,你
806could lose your license as a physician.可能会失去你的医生执照
807Metabolic therapy is patient driven.代谢疗法是病人驱动的.
808It's driven on the patient.驱于病人.
809What about hyperbaric oxygen?那高压氧气呢?
810Yeah, there was a study in 2013 that demonstrated that while a ketogenic diet对,2013年的一项研究 表明,当一种致病饮食
811alone significantly slowed tumor growth and systemic metastatic cancer mouse单是肿瘤生长和系统元病变小鼠就明显减缓
812models, combining the diet with hyperbaric oxygen therapy, elicited a将饮食与高血压氧气疗法结合起来,
813profound synergetic decrease in tumor growth and drastically increase survival肿瘤生长深度协同下降,存活率大幅提高.
814times.时间。
815我们和Dominic DiAgostino发表了论文。
816So we put mice, so listen, hyperbaric oxygen will create oxidative stress in所以,我们把小鼠, 所以听,超压氧 将产生氧化应激
817cells that do not have efficient oxidative phosphorylation.没有高效氧化磷化的细胞.
818Cancer cells.癌细胞.
819So you can kill cancer cells by oxidative stress by irradiating or poisoning them,这样你就可以通过辐照或毒害 氧化性应激作用杀死癌细胞,
820or you can put a patient in nutritional ketosis and then put them in hyperbaric或者你可以把病人 营养性酮化,然后让他们进入高压
821oxygen and the cancer cells are selectively killed.氧气和癌细胞被选择性地杀死.
822When you irradiate somebody, you're damaging the whole body with all kinds of当你辐照某人, 你正在破坏整个身体 以各种
823stuff.东西。
824And there's another thing, Steven, you got to listen to this and you listen还有一件事,史蒂芬,你得听这个,你听
825carefully.小心点
826When you go to these treat these standard of care, standard, when you use standard当你去这些治疗 这些护理的标准,标准, 当你使用标准
827of care, radiation, chemo, whatever they give you, immunotherapies or whatever.护理,辐射,化疗, 无论他们给你什么,免疫或其他什么。
828So the patient comes in and he says, I've been really working hard on this.病人进来说,我一直很努力
829The doctor says, Oh, no, that doesn't work.医生说,不,这行不通。
830Right.对
831Gives you some radiation or gives you, you go flying up into the red zone.给你一些辐射或给你, 你飞到红色区域。
832The treatment itself puts so much stress on the body that the body itself starts治疗本身给身体造成很大压力 导致身体本身开始
833going, you go into the red zone from the very treatments that you're giving to进入红色区域 从你给的治疗
834the patient, which is making strengthening the tumor cells.病人正在强化肿瘤细胞
835You're not against chemotherapy though, are you?你不是反对化疗吧?
836No, I'm, I'm, I'm positive about it, but it has to be used in the right context.不,我,我,我对此持肯定态度,但必须用在正确的上下文中.
837It has to be used when your body is in this new state of nutrition and you当你身体处于新的营养状态时 就必须用它
838can use low doses so you don't force the tumor cell to become even more可以使用低剂量 所以不要强迫肿瘤细胞变得更强
839resistant to the treatment.抗治疗.
840The next thing which is actionable is what you talked about earlier, which is接下来可以采取行动的是 你刚才谈到的
841these microplastics and forever chemicals in late 2023.这些微塑料和永远的化学物质 在2023年末。
842The international agency of research on cancer officially upgraded these forever癌症研究的国际机构 正式提升这些永远
843chemicals, which are used in non-stick pans and food packaging to a grade one化学品,用于非棒式锅和食品包装至一级
844carcinogen in humans, cancer causing in humans based on strong mechanistic人体致癌性,在强力机械作用下引起人体癌症
845evidence that it induces epigenetic, which is gene alterations and suppresses其诱发遗传学的证据,即基因改变和抑制
846the immune system.免疫系统。
847So you'd banned the forever chemicals.所以你禁止了永远的化学物质
848And this is a beautiful paper.这张报纸很漂亮
849I went back and I took what all of Otto Warburg meticulously went through all of我回去了,我拿走了所有奥托・沃堡 仔细地经历了所有
850his work, showed where he was absolutely correct and where he just didn't have他的作品,显示他在哪里绝对正确 和他只是没有
851the new information that would make him.新的信息会让他。
852I talked about the forever chemicals, microplastics.我说的是永远的化学物质 微塑料
853Guess what?你猜怎么着?
854They damaged the organelle.他们损坏了风琴
855They get into a break.他们进入了一个休息。
856They cause rostin damage and reduce the efficiency of oxidative phosphorylation它们造成罗丝汀损伤,降低氧化磷的氧化效率.
857causing a compensatory increase in the utilization of glucose and glutamine and使葡萄糖和谷氨酸的利用得到补偿性增加;
858dysregulated cell growth.抑制细胞生长.
859Everything comes back to this organelle.一切都回到这个风琴。
860All chronic diseases and cancer are the result of damage to this organelle.所有慢性病和癌症都是这种器官损伤的结果.
861That's why having this little thing here is so important.这就是为什么有这个小东西 在这里是如此重要。
862It's a great prop.道具绝妙.
863I ought to get one for my class.我该为我的班级买一个
864You can keep it.你可以留着它。
865The next thing is purifying the water supply.接下来是净化供水
866Heavy metals are found in local water supplies to run off and ultimately are在当地供水中发现重金属会流出,最终是
867carcinogenic in some cases.在某些情况下具有致癌性。
868The IARC classifies arsenic and cacadium as group on carcinogenics and they'reIARC将砷和镉分类为致癌物类,属于
869frequently found in unfiltered public water infrastructure.经常出现在未过滤的公共供水基础设施中。
870So you clean up the water supply as well.所以你也清理了供水系统
871You know, all this stuff is coming into our water supplies, people flushing down你知道,所有这些东西 进入我们的供水, 人们冲下来
872all these chemicals which then leach back into the water supply.所有这些化学物质 都浸回水中
873And every one of the chemicals that we have looked at that has been linked to我们所研究的每一种化学品 都与
874oncology or dysregulated cell growth all damage the oxidative phosphorylation肿瘤学或病变细胞生长均会损害氧化磷酸盐
875chronically.长期
876So we're bringing the entire focus back to things.因此,我们把整个焦点 带回事物。
877What can I do to keep this organelle healthy?我能做什么来保持这个风琴?
878Even if I'm exposed to these chemicals, if I can get into these zones like you're即使我接触到这些化学物质 如果我能像你们一样进入这些区域
879trying to do, so even if you are exposed to these, this organelle has an所以即使你接触到了这些 管风琴也有
880incredible healing power in itself.不可思议的治疗力量本身。
881What is the most important thing we haven't talked about that we should have最重要的事情是什么 我们没有谈论,我们应该有
882talked about Professor Thomas?谈到托马斯教授?
883Well, I mean, you've covered a lot.嗯,我的意思是,你已经覆盖了很多。
884One of the things I want to talk about is metastasis.我想谈的一件事是元化
885That's the spread of the tumor throughout the body.这就是肿瘤在整个体内的传播.
886OK, so if you were to have a cancer that's just localized in one spot, you好吧,所以如果你有一个癌症 它只是局部在一个斑点,你
887know, the probability of developing a therapy that would be long term is highly发展长期治疗的可能性很大
888increased.增加数。
889The problem that kills people is the spread.杀人的问题是传播。
890So if the tumor is in the breast and it spreads to the liver and the lungs and the因此,如果肿瘤在乳房中,并扩散到肝脏和肺部,
891brain, you know, you've got a problem.大脑,你知道,你有一个问题。
892Lung cancer spreads to the brain, the liver.肺癌传播至脑,肝.
893Most of these cancers that spread to the brain or other organs become difficult.这些传播到大脑或其他器官的癌症大多变得困难.
894And that's why you use systemic chemotherapy.这就是为什么你使用系统化疗。
895You're trying to stop.你试图停止。
896What we have found is that you have a stem cell.我们发现你有一个干细胞
897People love stem cells.人们喜欢干细胞.
898If you ever hear the term stem cell tumor, wow, stem cell如果你听说过干细胞瘤,哇,干细胞
899tumor, stem cell tumors cannot metastasize.肿瘤,干细胞肿瘤无法变形.
900How do I know?我怎么会知道?
901Because I had stem cell tumors diagnosed as stem cell tumors with因为我的干细胞瘤被诊断为干细胞瘤
902stem cell markers.干细胞标记.
903I've grown them.我长大了
904They grow very angry.他们变得非常愤怒。
905They get a lot of blood vessels, but they can't spread.它们得到许多血管,但无法传播.
906OK, how do you get spreading tumor cells in your body?好,你怎么在体内传播肿瘤细胞?
907The immune system comes in, recognizes that as an unhealed wound and then fuses免疫系统进入, 承认作为一个未愈合的伤口, 然后引信
908with the stem cells.与干细胞。
909And then you have these hybrid cells.然后你有了这些混合细胞。
910They are programmed to move around your body.他们被编程 在你的身体移动。
911So they are a macrophage tumor cell hybrid.因此,它们是一个宏phage肿瘤细胞杂交体。
912So and they're very hard to kill.所以他们很难杀
913But we found they're remarkably sensitive.但我们发现他们非常敏感
914They're glutamine driven.他们是谷氨酸驱动。
915So we know they're glutamine driven and they need the glucose.所以我们知道他们是谷氨酸驱动的 他们需要葡萄糖。
916And that's why metabolic therapy done the right way can nail those metastatic这就是为什么新陈代谢疗法 做正确的方式 能够钉这些元静态
917cancer cells, purging them with a little bit of immunotherapy to go along with it.癌细胞,用一点免疫疗法来净化它们,以便与之配合.
918You might be able to get what we call resolution.你也许能得到我们所说的解决
919别忘了,我的同事和我,Dom DiAgostino, Joe Maroon, 我们建造了
920press pulse therapeutic strategy.按脉冲治疗策略
921I mentioned that on your previous show.我在你之前的节目中提到过
922That's the way you press down the glucose of the tumor and then you pulse to kill这就是你按下肿瘤的葡萄糖 然后脉搏杀死
923the glutamine, which will which will target the metastatic cancer cells, enhancing谷氨酰胺,将针对元动癌细胞,增强
924the health and vitality of the organs already infiltrated by the tumor.肿瘤已经渗入的器官的健康和活力。
925I looked on our previous conversation, Professor Thomas, and it's quite我看了我们之前的谈话,托马斯教授, 这相当
926heartbreaking because the comments sections are all people that are either令人心碎,因为评论部分 是所有的人要么
927struggling themselves with cancer or a loved one of theirs, their wife, their与癌症搏斗 或一个爱的人 他们的妻子,他们的
928husband has just been diagnosed with cancer.丈夫刚刚被诊断患有癌症
929Is there anything for those people that have clicked on this video?有谁可以点击这段视频吗?
930Because I imagine they are in the millions that you want them to hear.因为我想他们会在你想要他们听到的几百万里
931Well, the thing of it is, is why, well, if this is a bigger issue, when you have那么,事情是,为什么,嗯, 如果这是一个更大的问题,当你有
932the science and you have the strategy to manage cancer effectively with minimal科学与你有策略 有效地管理癌症
933toxicity, not to say we can cure, but to say we can manage it, why is it not being毒性,不是说我们可以治愈, 而是说我们可以管理它,为什么它不是
934done?说完了吗?
935That's the question.问曰.
936But to them, to them who've tuned in.但对于他们, 对于他们调用。
937Okay.摆
938So these kinds of conversations that we have are allowing the populations to所以,这些类型的对话,我们有 允许民众
939realize that there is, their loved ones do not need to be sacrificed for the他们的爱人不需要牺牲
940good of industries that are generally considered profitable.有利可图的工业。
941In other words, the profitability of the industries are based on your sickness.换句话说,这些行业的盈利能力是基于你的疾病.
942And a lot of those comments came, oh, you can't do anything.很多评论都来了, 哦,你不能做任何事情。
943Yes, you can do something about it.是的,你可以做点什么。
944When you're armed with the knowledge and people ignore the knowledge, then当你掌握了知识 人们无视知识时
945there's a problem.有个问题
946Do people need to sort of self-advocate to some degree?人们需要某种程度的自我倡导吗?
947I think so.我想是这样。
948With that, with care providers, what do they?有了它,护理提供者,他们是什么?
949Yeah, I think that's a very delicate question.是的,我认为这是一个非常微妙的问题。
950The oncologists never heard of this stuff.肿瘤学家从来没有听说过这些东西。
951They have never read these papers.他们从未读过这些文件。
952They were never trained in medical school to know the biology and biochemistry of他们从未受过医学院的训练 以了解生物学和生物化学
953cancer.癌症。 癌症。
954It was told to be a genetic disease.据说是遗传性疾病
955Theories are so important in science.理论在科学中是如此重要.
956For 1,800 years, people thought the work of Aristotle, his comments and the1800年来,人们都认为亚里士多德的作品,他的评论和
957Claudius Talami的数学说 地球是太阳的中心
958system and all the planets and sun revolved around the earth, the geocentric所有行星和太阳环绕着地球 地心中心
959theory.理论
960Copernicus struggled with the Talami mathematics and realized that if he put哥白尼在塔拉米数学中挣扎 并意识到如果他把
961the sun in the center of the solar system and made earth just another planet, a太阳在太阳系中心 使地球成为另一个行星
962lot of the mathematics made sense.很多数学是有意义的。
963Kepler comes in and says, these aren't circles, they're ellipticals.开普勒进来说,这些不是圆的,是椭圆的.
964Galileo takes the telescope, sees the moons of Jupiter, and was able to look at伽利略拿着望远镜,看到木星的月亮, 并能看到
965and quantify where, predict where planets would be in a certain period of time.并量化 预测行星在一定时间内会在哪里
966Then they took poor Giordano Bruno.然后他们带走了可怜的乔达诺·布鲁诺.
967You know about this guy, Bruno?你知道这个家伙,布鲁诺?
968Oh, Steven, you got to know Bruno.史蒂芬,你得认识布鲁诺
969Your job is to know about the poor Bruno, who was burned alive by the Catholic你的工作是了解可怜的布鲁诺 他被天主教徒活活烧死
970church for challenging the geocentric theory.教会挑战地心理论
971And he became a martyr of science.他成为了科学的烈士.
972So when you have established power structure, whether it's a religion or因此,当你建立了权力结构, 无论它是一个宗教或
973whether it's an industry or whatever, challenging that can be very, very无论是行业还是什么 挑战性可以非常,非常
974hazardous.危险。
975Has it been hazardous for you?对你来说有危险吗?
976Listen, no, I mean, I do what I do because I like, I just collect more and more听着,不,我的意思是,我做什么, 因为我喜欢,我只是收集越来越多的
977data to support.要支持的数据。
978Hazardous for me would be getting blindsided.对我危险会变得盲目
979Blindsided would be somebody coming at me with a piece of new data that I have盲眼会有人用我的新数据来攻击我
980never considered.从来没有考虑过。
981I don't sleep, I think about this stuff all the time to avoid the blindside.我不睡觉,我总是想着这些东西 避开盲点。
982My students are on the alert for any paper that comes out that says cancer.我的学生们对任何写有癌症的论文都处于戒备状态.
983Oh, cancer cells can burn fatty acids and ketone bodies.癌细胞可以燃烧脂肪酸和酮体.
984Oh, really?是吗?
985Let's go back through and dissect out their control experiments.我们回去解剖他们的控制实验
986And you find that every case, there was always some glucose and glutamine in the你发现,每个病例, 总有一些葡萄糖和谷氨酸
987media making it look like the fatty acids.媒体让它看起来像脂肪酸。
988So, so that's what bothers me.所以,这就是困扰我的。
989What bothers me is getting hit with a piece of data that undermines what we're令我烦恼的是 被一个数据击中 破坏我们是什么
990what we our knowledge base is.我们的知识基础是什么。
991And so far, we haven't had that.到目前为止,我们还没有做到这一点。
992OK, it's we're standing on the shoulders of Otto Warburg, a giant in the field of好吧,这是我们站在奥托·沃堡的肩膀上 一个巨头在...
993biochemistry.生物化学.
994He was thrown under the bus when everybody thought cancer was a genetic disease.当所有人都认为癌症是遗传性疾病时,他被扔到巴士下.
995This paper goes back and shows exactly where Warburg made his mistakes and where这篇论文回过头来 确切地显示沃堡的错在哪里
996we have rectified some of that, bringing the whole field back on where it should我们纠正了其中的一些问题,使整个领域回到它应该回到的地方。
997be.将。
998It is a mitochondrial metabolic disorder, and we can account for all of这是一个线粒体代谢障碍, 我们可以解释所有
999the phenotypes and characteristics of that disease, knowing that.这种病的原型和特征
1000Now, with that knowledge, logical people and people interested in helping others现在,有了这种知识, 合乎逻辑的人和关心帮助别人的人
1001will will take advantage of that.将利用这一点。
1002We're not throwing out all these toxic chemicals.我们不会扔掉这些有毒化学品
1003We're learning how to use them in a different way.我们正在学习如何以不同的方式使用它们。
1004And that's where the success is going to come.然则成功将至.
1005So let's let's conclude with a actionable takeaway for people who are suffering所以,让我们最后 让我们有一个行动 外卖的人谁正在受苦
1006themselves with with cancers or have someone in their family right now that is自己患上了癌症 或者家里现在有人
1007suffering from cancers.患有癌症。
1008What is the actionable take?可采取的行动是什么?
1009Well, I think the action will take it.我想行动会成功的
1010Once this paper comes out, they can start taking action if they are motivated一旦这篇论文出来,他们就可以开始采取行动,如果他们有动机的话
1011enough.够了。
1012They can read about this.他们可以读到这一点。
1013They can read about it and then try to like just like you're doing.他们可以读到它,然后尝试喜欢 就像你正在做的。
1014No different.无异.
1015Get into these zones and then work with their oncologists,进入这些区域,然后与他们的肿瘤学家合作,
1016knowledgeable people to to to treat them with standards of care as long as they有知识的人只要能照顾到他们
1017can remain.可以留下来。
1018And then we do non-invasive imaging, PET scans, MRIs.然后我们做非入侵成像,PET扫描,MRI。
1019OK, so specifically what you're saying is this paper, I will link it below in the好吧,所以具体来说,你的意思是 这个文件,我会链接到下面的
1020comments section for anyone that wants to read it.任何想要阅读它的人的评论部分。
1021This graph will be on the screen throughout this episode anyway, so people这张图会一直出现在屏幕上 所以人们
1022can screenshot it if they want to have a look.可以截图 如果他们想看看。
1023And the way that they test what their GKI index is, is they can buy one of these他们测试GKI指数的方法 就是买一个
1024Keto Mojo things, which you can get on Amazon for twenty, thirty dollars.Keto Mojo的东西,你可以得到 在亚马逊20,30美元。
1025You prick your finger.你刺伤你的手指。
1026It gives you the glucose reading.它让你读葡萄糖。
1027Yeah, you divide it by 18.对,你除以18
1028No, no, the new machines have the button.不,不,新机器有按钮。
1029So even the people only have to do that.所以即使人们也只能这么做
1030OK, fine.好吧,没事。
1031And as you can see on here, this is an interesting way to sort of你可以看到,这是一个有趣的方式 排序
1032increase your your management, improve your management of some of these.增加您的管理, 改善您的管理 。
1033And then there's a challenge to get into those zones.接下来是进入这些区域的挑战。
1034You know, I'm not saying this is easy stuff.你知道,我不是说 这是容易的东西。
1035GLP one inhibitor, man, that's a hell of a lot easier than than than doing this.GLP 1抑制剂,伙计, 这比做这个容易得多。
1036And I should probably say always consult with a medical professional.我也许应该说,总是咨询 一个医学专业人员。
1037Yeah, I think because, you know, a lot of people, they have a lot of comorbidities.是的,我认为,因为,你知道, 很多人, 他们有很多的共性。
1038They have diabetes, high blood pressure, hypertension, cancer.他们有糖尿病,高血压,高血压,癌症.
1039They have a it's not a perfectly healthy person with cancer.他们有一个不完全健康的人 有癌症。
1040So before you go in to challenge that, you need to have what you look like.所以在挑战之前 你需要拥有你的样子
1041You might look, you know, you might have to be adjusted in some way.你可能看起来,你知道, 你可能不得不 以某种方式调整。
1042Yeah, that's why the people who the physicians that are working with this是啊,这就是为什么那些 医生工作的人
1043can do all that.可以做这一切。
1044I'm not in the clinical thing.我不是在临床的事情。
1045And there are some people who respond poorly to the ketogenic diet有些人对致病饮食反应不佳
1046and the high stakes of ketosis, because I've I've received DMs before from a woman我之前从一个女人那里收到过DM
1047who said my husband did ketosis and he collapsed unconscious.他说我丈夫做了Ketosis 他昏迷了
1048He took him to the hospital.他带他去医院
1049He had some comorbidity.他有点病态
1050Yeah.对
1051The other thing, too, is you got to be some people have carnitine deficiencies.另一件事,也是, 你必须是一些人 有肉硝素缺陷。
1052Carnitines prevents fatty acids from being made into ketone bodies.氨酸可以防止脂肪酸被制成酮体.
1053So so they can be carnitine supplementation can help them.因此它们可以做肉硝酸补充剂可以帮助它们.
1054But you need a physician to know this.但你需要医生来知道这件事
1055We have a closing tradition with the last question for the next.我们有一个关闭的传统 最后一个问题,下一个。
1056And the question left for you is on the subject of energy.留给你的问题是能量问题。
1057What in your life has brought you the most energy?你生命中有什么带来最大的能量?
1058And what was the biggest energy drain you've ever experienced?你经历过最大的能量排水量是什么?
1059This is bringing me the biggest energy.这给我带来了最大的能量。
1060Yes.对
1061Well, that is the whole concept.这就是整个概念。
1062The idea that you have found你发现的想法
1063mother nature has allowed you to look into the depths母亲的本性允许你深入调查
1064of of of what we consider the biology and biochemistry of how bodies work关于我们所认为的 生物和生物化学 如何工作
1065and knowing how to take that and apply it to people that are suffering并知道如何采取 并应用到正在受苦的人
1066from all these different chronic diseases and giving them从所有这些不同的慢性病 并给予他们
1067the opportunity to change that.机会改变这一点。
1068Because before that, it was mysterious.因为在那之前,这是神秘的。
1069Oh, I'm I'm in Quito.哦,我在基多。
1070What's your GK?你的GK怎么样?
1071I don't know.师曰.
1072Well, now you have a quantitative opportunity that gets us.现在,你有一个量化的机会 给我们。
1073So we have a lot of evidence.我们有很多证据
1074I think people should be feeling encouraged.我认为人们应该感到鼓励。
1075I think we have given hope to the hopeless.我认为我们已经给绝望的人带来了希望。
1076And I think that's empowering.我认为这是赋予权力。
1077And the goal here is not to make a billion dollars.这里的目标不是创造十亿美元。
1078It's just to know that you've kept all these poor souls alive只是想知道你让这些可怜的灵魂活着
1079longer than they were projected to be to be.时间长于预计。
1080And I think this power that that keeps us going.我认为这种力量能让我们继续前进。
1081Because when we see more and more people coming to me,因为当我们看到越来越多的人来找我
1082I get emails back from people three or four years ago.三四年前我收到人们的邮件
1083And I said, you know, I thought you were a goner.我说,你知道,我还以为你死了。
1084And he says, I'm doing really well.他说,我做得很好。
1085Just came back from a vacation with my wife.刚和我老婆度假回来
1086Well, that's empowering.嗯,这是授权。
1087I said, well, that's good.我说,很好
1088And don't forget, Steven, all of our research money别忘了,史蒂文,我们所有的研究经费
1089comes from private foundations and philanthropy.来自于私人基金会和慈善事业.
1090So so is that a way that people can help?那么,这是人们可以帮助的方式吗?
1091Yeah.对
1092And where do they go?他们去哪里?
1093Oh, Travis Christopherson's foundation.哦,特拉维斯克里斯托弗森的基金会。
1094So we in my papers, we have the foundations因此,我们在我的论文, 我们有基础
1095that support our work, private foundations.支持我们的工作,私人基金会。
1096And there are occasionally, yes, please link.有的时候,是的,请链接。
1097There are occasionally people I know.偶尔也有我认识的人
1098And when I give kits of information to people,当我把信息包给别人
1099I say, please consider making a donation我说,请考虑捐款
1100only if it works for you.只有在它为你工作。
1101Don't charge them anything or ask them to pay something不要收钱,要他们付钱
1102if it's not going to help them.如果它不会帮助他们。
1103If you were told to be dead in six months如果你被告知六个月后就死了
1104and six years later in your life,在你生命的六年后,
1105maybe throw us a few shekels into the private也许给我们一些谢克尔的私事
1106found into the foundation supporting our work.成为支持我们工作的基金会
1107I'll link that foundation below in the comments.我将在下面的评论中将基金会联系起来。
1108Yeah, we have a couple on breast cancer, on on general是啊,我们有一对夫妇 关于乳腺癌,关于一般
1109general support on the metabolic approach that we have.普遍支持我们的新陈代谢方法
1110So we have a lot going.所以我们有很多事情要做
1111We're very excited.我们很兴奋
1112And you can see all the papers we've published.你可以看到我们发表的所有论文。
1113It's not like some of these are in top journals.这不像是一些 在顶级期刊上。
1114Some of them are new journals.其中一些是新刊物。
1115But but the issue is we're we're we're we're publishing this.但问题是我们要发表这个
1116My thing is, you know, I great, great, great respect for science我的问题是,你知道, 我伟大的,伟大的,非常尊重科学
1117and doctors in the medical profession.以及医生
1118Go, go, go get your information.去,去,去得到你的信息。
1119Speak to medical provider.与医方说言.
1120There's so many tools out there now.现在有这么多的工具
1121Go and check for yourself.你自己去检查一下
1122Yeah, well, I think in the oncology field,是啊,我想在肿瘤领域,
1123that's where we have this vast wasteland of misinformation这就是我们拥有一个巨大的荒原 错误信息
1124or misunderstanding.或误解。
1125Let's put it that way.这么说吧
1126They don't understand these concepts where, you know,他们不明白这些概念在哪里,你知道,
1127people who have done heart work and bone work and replacements,做心脏工作 骨骼工作 和替换,
1128those people are at the state of the art with this kind of stuff.这些人在最先进的 此类的东西。
1129Well, the last conversation we had has reached about 15 million people.上次我们的对话 已经达到了1500万人。
1130So on YouTube, it's got 10 million views.所以在YouTube上,它有1000万的浏览量.
1131And then across audio platforms,然后穿过音频平台,
1132it's got another five or so million views.它还有五百万个视图
1133And when I read through the comments sections, it's just it's so heartening当我读到评论部分, 它只是如此令人振奋
1134for two reasons.有两个原因。
1135One is you're giving people tools and science that they can think about第一,你给人们工具和科学 他们可以思考
1136and research themselves and speak to the medical practitioner about.自己去研究,跟医生谈谈
1137But also it actually just creates a community of people in the comments但实际上,它只是 创建一个社群 人们在评论
1138section where this is a community of people that are searching for hope.这是一群人民在寻找希望
1139Yeah.对
1140And as some of them read through the comments sections,当其中一些人从评论部分读到
1141they actually commented saying it was so nice to to speak to other people他们实际上评论说 和别人说话真好
1142in the comments sections about what I'm going through关于我所经历的一切
1143and how it feels from an emotional level.以及情感层面的感受
1144So this is something I actually wanted to say in this episode was我本集想说的是
1145if you're if you're listening to this conversation如果你在听这个谈话的话
1146and you've gotten to this point, do you feel free to go into the comments你已经到了这个地步, 你觉得可以自由 进入评论
1147section and just offer some support and some love to other people给别人一些支持和爱
1148who are struggling because, you know, it can be a very lonely experience他们正在挣扎 因为,你知道,这可能是 一个非常孤独的经历
1149the minute you find out you've got a diagnosis and off you go into the internet,一旦你发现自己有诊断结果 你就上网
1150into podcasts, into AI to try and figure out what you can do.进入播客,进入AI 尝试并找出你能做什么。
1151So, yeah, do share things that have helped you所以,是的,做一些事情 帮助你
1152point at different resources that are rigorous and offer emotional support在不同的资源 严谨和提供情感支持
1153to those that are in the comments section.改为评论部分。
1154That would be a wonderful thing.这会是一件很棒的事。
1155Thomas, thank you so much for all that you do.托马斯,谢谢你所做的一切
1156You're an absolute worrier for pushing science, the science into the world你是一个绝对的烦恼 推动科学,科学进入世界
1157and for fighting for these people that don't have the tools.为了这些没有工具的人而战
1158And if you I mean, I don't think I've ever seen a comment section如果你,我的意思是, 我不认为我见过 评论部分
1159quite like it in terms of the gratitude that people have for the work在人们对作品的感激方面 很喜欢
1160that you're doing.你这样做。
1161It is remarkable work.这是了不起的工作。
1162Long may you continue to do it.愿你继续做下去
1163Thank you very much.谢谢
1164And, you know, you play a very important part on this而且,你知道, 你扮演一个非常重要的角色
1165because this information is not disseminated to the population因为这种信息没有向民众传播;
1166and it's the population of people that will eventually make the change.最终会改变的是人口
1167So they're going to want this, especially when we keep publishing所以,他们会想要这个, 特别是当我们继续出版
1168more and more case reports of successful cases.越来越多的成功案例报告。
1169And the system will change and we just have to modify系统会改变,我们只需要修改
1170what we have to make it better.我们要做的更好
1171And I think that's what keeps us going.我认为这就是我们继续前进的原因。
1172So I have no plans of stopping this anytime soon.所以,我没有计划 停止这一切的任何时间。
1173My students are all excited about this.我的学生都对此感到兴奋。
1174They're learning about it at Boston College.他们在波士顿学院学习
1175So this is a big emphasis that we have and we continue to do it again.因此,这是我们的一大重点,我们继续这样做。
1176Scientific literacy is so important for how you navigate through life.科学知识对于你如何引导人生非常重要
1177And thank you very much for your show.谢谢你的表演
1178And we'll keep pushing this as hard as we can.我们会尽力推动
1179Thank you.谢谢
1180YouTube have this new crazy algorithm where they know exactlyYouTube有一个新的疯狂的算法 他们确切知道
1181what video you would like to watch next based on AI你接下来想看什么基于AI的视频
1182and all of your viewing behavior.还有你所有的观赏行为
1183And the algorithm says that this video is the perfect video算法上说这个视频是完美的视频
1184for you.给你的
1185It's different for everybody looking right now.现在每个人看起来都不一样
1186Check this video out.看看这个视频
1187I bet you you might love it.我打赌你会喜欢的
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